Epstein-Barr virus infection of Langerhans cell precursors as a mechanism of oral epithelial entry, persistence, and reactivation

Dennis M. Walling, Autumn J. Ray, Joan Nichols, Catherine M. Flaitz, C. Mark Nichols

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus associated with many malignant and nonmalignant human diseases. Life-long latent EBV persistence occurs in blood-borne B lymphocytes, while EBV intermittently productively replicates in mucosal epithelia. Although several models have previously been proposed, the mechanism of EBV transition between these two reservoirs of infection has not been determined. In this study, we present the first evidence demonstrating that EBV latently infects a unique subset of blood-borne mononuclear cells that are direct precursors to Langerhans cells and that EBV both latently and productively infects oral epithelium-resident cells that are likely Langerhans cells. These data form the basis of a proposed new model of EBV transition from blood to oral epithelium in which EBV-infected Langerhans cell precursors serve to transport EBV to the oral epithelium as they migrate and differentiate into oral Langerhans cells. This new model contributes fresh insight into the natural history of EBV infection and the pathogenesis of EBV-associated epithelial disease.

Original languageEnglish (US)
Pages (from-to)7249-7268
Number of pages20
JournalJournal of Virology
Volume81
Issue number13
DOIs
StatePublished - Jul 2007

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Langerhans cells
Human herpesvirus 4
Epstein-Barr Virus Infections
Langerhans Cells
Human Herpesvirus 4
mouth
infection
Epithelium
epithelium
blood
Herpesviridae
natural history
human diseases
B-lymphocytes
B-Lymphocytes
pathogenesis

ASJC Scopus subject areas

  • Immunology

Cite this

Epstein-Barr virus infection of Langerhans cell precursors as a mechanism of oral epithelial entry, persistence, and reactivation. / Walling, Dennis M.; Ray, Autumn J.; Nichols, Joan; Flaitz, Catherine M.; Nichols, C. Mark.

In: Journal of Virology, Vol. 81, No. 13, 07.2007, p. 7249-7268.

Research output: Contribution to journalArticle

Walling, Dennis M. ; Ray, Autumn J. ; Nichols, Joan ; Flaitz, Catherine M. ; Nichols, C. Mark. / Epstein-Barr virus infection of Langerhans cell precursors as a mechanism of oral epithelial entry, persistence, and reactivation. In: Journal of Virology. 2007 ; Vol. 81, No. 13. pp. 7249-7268.
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