Equine amplification and virulence of subtype IE Venezuelan equine encephalitis viruses isolated during the 1993 and 1996 Mexican epizootics

Dante Gonzalez-Salazar, José G. Estrada-Franco, Anne Sophie Carrara, Judith Aronson, Scott Weaver

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

To assess the role of horses as amplification hosts during the 1993 and 1996 Mexican Venezuelan equine encephalitis (VEE) epizootics, we subcutaneously infected 10 horses by using four different equine isolates. Most horses showed little or no disease and low or nonexistent viremia. Neurologic disease developed in only 1 horse, and brain histopathologic examination showed meningeal lymphocytic infiltration, perivascular cuffing, and focal encephalitis. Three animals showed mild meningoencephalitis without clinical disease. Viral RNA was detected in the brain of several animals 12-14 days after infection. These data suggest that the duration and scope of the recent Mexican epizootics were limited by lack of equine amplification characteristic of previous, more extensive VEE outbreaks. The Mexican epizootics may have resulted from the circulation of a more equine-neurotropic, subtype IE virus strain or from increased transmission to horses due to amplification by other vertebrate hosts or transmission by more competent mosquito vectors.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalEmerging Infectious Diseases
Volume9
Issue number2
StatePublished - Feb 1 2003

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Venezuelan Equine Encephalitis Viruses
Horses
Virulence
Venezuelan Equine Encephalomyelitides
Meningoencephalitis
Viremia
Brain
Viral RNA
Encephalitis
Nervous System Diseases
Disease Outbreaks
Vertebrates
Viruses

ASJC Scopus subject areas

  • Microbiology (medical)

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Equine amplification and virulence of subtype IE Venezuelan equine encephalitis viruses isolated during the 1993 and 1996 Mexican epizootics. / Gonzalez-Salazar, Dante; Estrada-Franco, José G.; Carrara, Anne Sophie; Aronson, Judith; Weaver, Scott.

In: Emerging Infectious Diseases, Vol. 9, No. 2, 01.02.2003, p. 161-168.

Research output: Contribution to journalArticle

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