Eradication of Candida burn wound septicemia in massively burned patients

M. H. Desai, David Herndon

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The increased incidence of Candida burn wound infection and septicemia in massively burned patients is well known. One thousand thirty six patients were admitted from January 1982 through December 1986. Nystatin prophylaxis, both oral and topical, was initiated in October 1984 and 472 patients were treated. The control group was comprised of the 564 patients treated January 1982 through September 1984. There was a significant difference (p < 0.005) between the groups in the number of Candida colonized patients, the numbers of Candida burn wound infections, the incidence of multi-organ system involvement/failure, and the occurrence of Candida sepsis. There has not been a Candida burn wound infection in this institution since June 1985. Nystatin, given orally as a 'swish and swallow' or mixed 1:1 with either silver sulfadiazine or polymyxin B/bacitracin, has eradicated Candida burn wound infections and septicemia from this institution and thus obviated the need for systemic antifungals such as amphotericin B.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalJournal of Trauma
Volume28
Issue number2
StatePublished - 1988

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Candida
Sepsis
Wound Infection
Wounds and Injuries
Nystatin
Silver Sulfadiazine
Incidence
Amphotericin B
Deglutition
Control Groups

ASJC Scopus subject areas

  • Surgery

Cite this

Eradication of Candida burn wound septicemia in massively burned patients. / Desai, M. H.; Herndon, David.

In: Journal of Trauma, Vol. 28, No. 2, 1988, p. 140-145.

Research output: Contribution to journalArticle

Desai, MH & Herndon, D 1988, 'Eradication of Candida burn wound septicemia in massively burned patients', Journal of Trauma, vol. 28, no. 2, pp. 140-145.
Desai, M. H. ; Herndon, David. / Eradication of Candida burn wound septicemia in massively burned patients. In: Journal of Trauma. 1988 ; Vol. 28, No. 2. pp. 140-145.
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