ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: Implications towards sensitization to apoptosis

Keyphrases

• Apoptosis 100%
• Phosphoinositide 3-kinase (PI3K) 100%
• Transcriptional Activity 100%
• Transcriptional Repressor 100%
• Signal Transducer 100%
• Negatively Regulate 100%
• Human Melanoma Cells 100%
• PD98059 80%
• LY294002 60%
• Tyrosine Phosphorylation 40%
• Melanoma 40%
• AKT1 40%
• Nuclear Translocation 20%
• Signaling Pathway 20%
• Growth Factors 20%
• Protein Kinase 20%
• Pharmacological Inhibitors 20%
• Activating mutation 20%
• Signal Transducer and Activator of Transcription Protein 20%
• Expression Level 20%
• Activity Level 20%
• Extracellular Stimuli 20%
• Melanoma Cells 20%
• Basal Level 20%
• MEK-ERK 20%
• Basal Activity 20%
• Janus Kinase 2 (JAK2) 20%
• Transcription Activity 20%
• B-Raf 20%
• Growth Stress 20%
• JAK-STAT 20%

Biochemistry, Genetics and Molecular Biology

• Transcription 100%
• Sensitization 100%
• Programmed Cell Death 100%
• Mitogen-Activated Protein Kinase 80%
• LY294002 60%
• Protein Kinase B 40%
• Tyrosine Phosphorylation 40%
• Growth Factor 20%
• Cytokine 20%
• Tumor Necrosis Factor 20%
• STAT3 20%
• Protein Kinases 20%
• TRAIL 20%
• STAT Protein 20%
• Janus Kinase 20%
• JAK-STAT Signaling Pathway 20%
• JAK-STAT Signaling 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Melanoma 100%
• 2 (2 Amino 3 Methoxyphenyl)chromone 100%
• 2 Morpholino 8 Phenylchromone 75%
• Protein Kinase B 50%
• Growth Factor 25%
• Cytokine 25%
• Tumor Necrosis Factor 25%
• Protein Kinases 25%
• Janus Kinase 25%
• STAT Protein 25%
• JAK-STAT Signaling 25%