Erythrocyte nuclei resemble dying neurons in embryonic dorsal root ganglia

Richard E. Coggeshall, Carolyn M. Pover, Geoffrey C. Kwait, Maria Fitzgerald

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cell death or apoptosis is regarded as an important feature of mammalian neural development, but the evidence for this generalization depends on the assumption that cell death can be clearly recognized. The usual profile of a dying neuron is a deeply stained pyknotic homogeneous sphere. In this paper we present evidence that such profiles in embryonic rat T6 and L4 dorsal root ganglia are not dying neurons but rather nuclei of immature red blood cells. This observation, combined with recent work showing that the methods previously used for counting normal or dying neurons are biased, indicates that the classic work establishing the importance of apoptosis needs to be repeated.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalNeuroscience Letters
Volume157
Issue number1
DOIs
StatePublished - Jul 9 1993

Fingerprint

Spinal Ganglia
Erythrocytes
Neurons
Cell Death
Apoptosis

Keywords

  • Apoptosis
  • Dorsal root ganglion cell
  • Neural development

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Erythrocyte nuclei resemble dying neurons in embryonic dorsal root ganglia. / Coggeshall, Richard E.; Pover, Carolyn M.; Kwait, Geoffrey C.; Fitzgerald, Maria.

In: Neuroscience Letters, Vol. 157, No. 1, 09.07.1993, p. 41-44.

Research output: Contribution to journalArticle

Coggeshall, RE, Pover, CM, Kwait, GC & Fitzgerald, M 1993, 'Erythrocyte nuclei resemble dying neurons in embryonic dorsal root ganglia', Neuroscience Letters, vol. 157, no. 1, pp. 41-44. https://doi.org/10.1016/0304-3940(93)90638-2
Coggeshall, Richard E. ; Pover, Carolyn M. ; Kwait, Geoffrey C. ; Fitzgerald, Maria. / Erythrocyte nuclei resemble dying neurons in embryonic dorsal root ganglia. In: Neuroscience Letters. 1993 ; Vol. 157, No. 1. pp. 41-44.
@article{1bc40e022b414cb6b7094b3b2ef087f4,
title = "Erythrocyte nuclei resemble dying neurons in embryonic dorsal root ganglia",
abstract = "Cell death or apoptosis is regarded as an important feature of mammalian neural development, but the evidence for this generalization depends on the assumption that cell death can be clearly recognized. The usual profile of a dying neuron is a deeply stained pyknotic homogeneous sphere. In this paper we present evidence that such profiles in embryonic rat T6 and L4 dorsal root ganglia are not dying neurons but rather nuclei of immature red blood cells. This observation, combined with recent work showing that the methods previously used for counting normal or dying neurons are biased, indicates that the classic work establishing the importance of apoptosis needs to be repeated.",
keywords = "Apoptosis, Dorsal root ganglion cell, Neural development",
author = "Coggeshall, {Richard E.} and Pover, {Carolyn M.} and Kwait, {Geoffrey C.} and Maria Fitzgerald",
year = "1993",
month = "7",
day = "9",
doi = "10.1016/0304-3940(93)90638-2",
language = "English (US)",
volume = "157",
pages = "41--44",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Erythrocyte nuclei resemble dying neurons in embryonic dorsal root ganglia

AU - Coggeshall, Richard E.

AU - Pover, Carolyn M.

AU - Kwait, Geoffrey C.

AU - Fitzgerald, Maria

PY - 1993/7/9

Y1 - 1993/7/9

N2 - Cell death or apoptosis is regarded as an important feature of mammalian neural development, but the evidence for this generalization depends on the assumption that cell death can be clearly recognized. The usual profile of a dying neuron is a deeply stained pyknotic homogeneous sphere. In this paper we present evidence that such profiles in embryonic rat T6 and L4 dorsal root ganglia are not dying neurons but rather nuclei of immature red blood cells. This observation, combined with recent work showing that the methods previously used for counting normal or dying neurons are biased, indicates that the classic work establishing the importance of apoptosis needs to be repeated.

AB - Cell death or apoptosis is regarded as an important feature of mammalian neural development, but the evidence for this generalization depends on the assumption that cell death can be clearly recognized. The usual profile of a dying neuron is a deeply stained pyknotic homogeneous sphere. In this paper we present evidence that such profiles in embryonic rat T6 and L4 dorsal root ganglia are not dying neurons but rather nuclei of immature red blood cells. This observation, combined with recent work showing that the methods previously used for counting normal or dying neurons are biased, indicates that the classic work establishing the importance of apoptosis needs to be repeated.

KW - Apoptosis

KW - Dorsal root ganglion cell

KW - Neural development

UR - http://www.scopus.com/inward/record.url?scp=0027249887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027249887&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(93)90638-2

DO - 10.1016/0304-3940(93)90638-2

M3 - Article

VL - 157

SP - 41

EP - 44

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -