Esophageal perforation and pneumomediastinum: Rare complications of tuberculosis

Alwyn Rapose, Ashutosh Naniwadekar, Bilal Sarvat, Juan C. Sarria

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A 54-year-old HIV-positive African American man was diagnosed with esophageal tuberculosis. His condition was complicated by esophageal perforation and pneumomediastinum. When treated with isoniazid, rifampin, ethambutol, and pyrazinamide, he developed medication-induced hepatitis. Streptomycin and levofloxacin were used as alternative agents along with isoniazid and ethambutol, which were tolerated well. At the end of 2 months, there was clinical improvement and resolution of pneumomediastinum. Surgery was not required. This is the first report of successful treatment of tuberculosis-related esophageal perforation and pneumomediastinum using second-line antituberculous agents.

Original languageEnglish (US)
Pages (from-to)266-267
Number of pages2
JournalInfectious Diseases in Clinical Practice
Issue number4
StatePublished - Jul 2008

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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