Esophageal perforation and pneumomediastinum

Rare complications of tuberculosis

Alwyn Rapose, Ashutosh Naniwadekar, Bilal Sarvat, Juan Sarria

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 54-year-old HIV-positive African American man was diagnosed with esophageal tuberculosis. His condition was complicated by esophageal perforation and pneumomediastinum. When treated with isoniazid, rifampin, ethambutol, and pyrazinamide, he developed medication-induced hepatitis. Streptomycin and levofloxacin were used as alternative agents along with isoniazid and ethambutol, which were tolerated well. At the end of 2 months, there was clinical improvement and resolution of pneumomediastinum. Surgery was not required. This is the first report of successful treatment of tuberculosis-related esophageal perforation and pneumomediastinum using second-line antituberculous agents.

Original languageEnglish (US)
Pages (from-to)266-267
Number of pages2
JournalInfectious Diseases in Clinical Practice
Volume16
Issue number4
DOIs
StatePublished - Jul 2008

Fingerprint

Esophageal Perforation
Mediastinal Emphysema
Ethambutol
Tuberculosis
Isoniazid
Pyrazinamide
Levofloxacin
Streptomycin
Rifampin
African Americans
Hepatitis
HIV
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Esophageal perforation and pneumomediastinum : Rare complications of tuberculosis. / Rapose, Alwyn; Naniwadekar, Ashutosh; Sarvat, Bilal; Sarria, Juan.

In: Infectious Diseases in Clinical Practice, Vol. 16, No. 4, 07.2008, p. 266-267.

Research output: Contribution to journalArticle

Rapose, Alwyn ; Naniwadekar, Ashutosh ; Sarvat, Bilal ; Sarria, Juan. / Esophageal perforation and pneumomediastinum : Rare complications of tuberculosis. In: Infectious Diseases in Clinical Practice. 2008 ; Vol. 16, No. 4. pp. 266-267.
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