TY - JOUR
T1 - Esophageal perforation and pneumomediastinum
T2 - Rare complications of tuberculosis
AU - Rapose, Alwyn
AU - Naniwadekar, Ashutosh
AU - Sarvat, Bilal
AU - Sarria, Juan C.
PY - 2008/7
Y1 - 2008/7
N2 - A 54-year-old HIV-positive African American man was diagnosed with esophageal tuberculosis. His condition was complicated by esophageal perforation and pneumomediastinum. When treated with isoniazid, rifampin, ethambutol, and pyrazinamide, he developed medication-induced hepatitis. Streptomycin and levofloxacin were used as alternative agents along with isoniazid and ethambutol, which were tolerated well. At the end of 2 months, there was clinical improvement and resolution of pneumomediastinum. Surgery was not required. This is the first report of successful treatment of tuberculosis-related esophageal perforation and pneumomediastinum using second-line antituberculous agents.
AB - A 54-year-old HIV-positive African American man was diagnosed with esophageal tuberculosis. His condition was complicated by esophageal perforation and pneumomediastinum. When treated with isoniazid, rifampin, ethambutol, and pyrazinamide, he developed medication-induced hepatitis. Streptomycin and levofloxacin were used as alternative agents along with isoniazid and ethambutol, which were tolerated well. At the end of 2 months, there was clinical improvement and resolution of pneumomediastinum. Surgery was not required. This is the first report of successful treatment of tuberculosis-related esophageal perforation and pneumomediastinum using second-line antituberculous agents.
UR - http://www.scopus.com/inward/record.url?scp=67649945521&partnerID=8YFLogxK
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U2 - 10.1097/IPC.0b013e318162a992
DO - 10.1097/IPC.0b013e318162a992
M3 - Article
AN - SCOPUS:67649945521
SN - 1056-9103
VL - 16
SP - 266
EP - 267
JO - Infectious Diseases in Clinical Practice
JF - Infectious Diseases in Clinical Practice
IS - 4
ER -