Establishment and lineage replacement of h6 influenza viruses in domestic ducks in southern china

Kai Huang, Huachen Zhu, Xiaohui Fan, Jia Wang, Chung Lam Cheung, Lian Duan, Wenshan Hong, Yongmei Liu, Lifeng Li, David K. Smith, Honglin Chen, Robert G. Webster, Richard J. Webby, Malik Peiris, Yi Guan

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Domestic ducks in southern China act as an important reservoir for influenza viruses and have also facilitated the establishment of multiple H6 influenza virus lineages. To understand the continuing evolution of these established lineages, 297 H6 viruses isolated from domestic ducks during 2006 and 2007 were genetically and antigenically analyzed. Phylogenetic analyses showed that group II duck H6 viruses had replaced the previously predominant group I lineage and extended their geographic distribution from coastal to inland regions. Group II H6 virus showed that the genesis and development of multiple types of deletions in the neuraminidase (NA) stalk region could occur in the influenza viruses from domestic ducks. A gradual replacement of the N2 NA subtype with N6 was observed. Significant antigenic changes occurred within group II H6 viruses so that they became antigenically distinguishable from group I and gene pool viruses. Gene exchange between group II H6 viruses and the established H5N1, H9N2, or H6N1 virus lineages in poultry in the region was very limited. These findings suggest that domestic ducks can facilitate significant genetic and antigenic changes in viruses established in this host and highlight gaps in our knowledge of influenza virus ecology and even the evolutionary behavior of this virus family in its aquatic avian reservoirs.

Original languageEnglish (US)
Pages (from-to)6075-6083
Number of pages9
JournalJournal of virology
Volume86
Issue number11
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

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Ducks
Orthomyxoviridae
ducks
China
Viruses
viruses
Neuraminidase
sialidase
H5N1 Subtype Influenza A Virus
Gene Pool
Poultry
Ecology
geographical distribution
poultry
ecology
phylogeny

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Establishment and lineage replacement of h6 influenza viruses in domestic ducks in southern china. / Huang, Kai; Zhu, Huachen; Fan, Xiaohui; Wang, Jia; Cheung, Chung Lam; Duan, Lian; Hong, Wenshan; Liu, Yongmei; Li, Lifeng; Smith, David K.; Chen, Honglin; Webster, Robert G.; Webby, Richard J.; Peiris, Malik; Guan, Yi.

In: Journal of virology, Vol. 86, No. 11, 01.06.2012, p. 6075-6083.

Research output: Contribution to journalArticle

Huang, K, Zhu, H, Fan, X, Wang, J, Cheung, CL, Duan, L, Hong, W, Liu, Y, Li, L, Smith, DK, Chen, H, Webster, RG, Webby, RJ, Peiris, M & Guan, Y 2012, 'Establishment and lineage replacement of h6 influenza viruses in domestic ducks in southern china', Journal of virology, vol. 86, no. 11, pp. 6075-6083. https://doi.org/10.1128/JVI.06389-11
Huang, Kai ; Zhu, Huachen ; Fan, Xiaohui ; Wang, Jia ; Cheung, Chung Lam ; Duan, Lian ; Hong, Wenshan ; Liu, Yongmei ; Li, Lifeng ; Smith, David K. ; Chen, Honglin ; Webster, Robert G. ; Webby, Richard J. ; Peiris, Malik ; Guan, Yi. / Establishment and lineage replacement of h6 influenza viruses in domestic ducks in southern china. In: Journal of virology. 2012 ; Vol. 86, No. 11. pp. 6075-6083.
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