Establishment of multiple sublineages of H5N1 influenza virus in Asia

Implications for pandemic control

H. Chen, G. J.D. Smith, K. S. Li, J. Wang, X. H. Fan, J. M. Rayner, D. Vijaykrishna, J. X. Zhang, L. J. Zhang, C. T. Guo, C. L. Cheung, K. M. Xu, L. Duan, Kai Huang, K. Qin, Y. H.C. Leung, W. L. Wu, H. R. Lu, Y. Chen, N. S. Xia & 8 others T. S.P. Naipospos, K. Y. Yuen, S. S. Hassan, S. Bahri, T. D. Nguyen, R. G. Webster, J. S.M. Peiris, Y. Guan

Research output: Contribution to journalArticle

480 Citations (Scopus)

Abstract

Preparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity.

Original languageEnglish (US)
Pages (from-to)2845-2850
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number8
DOIs
StatePublished - Feb 21 2006
Externally publishedYes

Fingerprint

H5N1 Subtype Influenza A Virus
Pandemics
Orthomyxoviridae
Poultry
China
Southeastern Asia
Birds
Viruses
Antigenic Variation
Influenza in Birds
Indonesia
Vietnam
Thailand
Infection Control
Human Influenza
Infection

Keywords

  • Avian
  • Genetics
  • Human
  • Influenza A
  • Virus evolution

ASJC Scopus subject areas

  • General

Cite this

Establishment of multiple sublineages of H5N1 influenza virus in Asia : Implications for pandemic control. / Chen, H.; Smith, G. J.D.; Li, K. S.; Wang, J.; Fan, X. H.; Rayner, J. M.; Vijaykrishna, D.; Zhang, J. X.; Zhang, L. J.; Guo, C. T.; Cheung, C. L.; Xu, K. M.; Duan, L.; Huang, Kai; Qin, K.; Leung, Y. H.C.; Wu, W. L.; Lu, H. R.; Chen, Y.; Xia, N. S.; Naipospos, T. S.P.; Yuen, K. Y.; Hassan, S. S.; Bahri, S.; Nguyen, T. D.; Webster, R. G.; Peiris, J. S.M.; Guan, Y.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 8, 21.02.2006, p. 2845-2850.

Research output: Contribution to journalArticle

Chen, H, Smith, GJD, Li, KS, Wang, J, Fan, XH, Rayner, JM, Vijaykrishna, D, Zhang, JX, Zhang, LJ, Guo, CT, Cheung, CL, Xu, KM, Duan, L, Huang, K, Qin, K, Leung, YHC, Wu, WL, Lu, HR, Chen, Y, Xia, NS, Naipospos, TSP, Yuen, KY, Hassan, SS, Bahri, S, Nguyen, TD, Webster, RG, Peiris, JSM & Guan, Y 2006, 'Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 8, pp. 2845-2850. https://doi.org/10.1073/pnas.0511120103
Chen, H. ; Smith, G. J.D. ; Li, K. S. ; Wang, J. ; Fan, X. H. ; Rayner, J. M. ; Vijaykrishna, D. ; Zhang, J. X. ; Zhang, L. J. ; Guo, C. T. ; Cheung, C. L. ; Xu, K. M. ; Duan, L. ; Huang, Kai ; Qin, K. ; Leung, Y. H.C. ; Wu, W. L. ; Lu, H. R. ; Chen, Y. ; Xia, N. S. ; Naipospos, T. S.P. ; Yuen, K. Y. ; Hassan, S. S. ; Bahri, S. ; Nguyen, T. D. ; Webster, R. G. ; Peiris, J. S.M. ; Guan, Y. / Establishment of multiple sublineages of H5N1 influenza virus in Asia : Implications for pandemic control. In: Proceedings of the National Academy of Sciences of the United States of America. 2006 ; Vol. 103, No. 8. pp. 2845-2850.
@article{a523a21758ca4bde81a10536f99d3940,
title = "Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control",
abstract = "Preparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity.",
keywords = "Avian, Genetics, Human, Influenza A, Virus evolution",
author = "H. Chen and Smith, {G. J.D.} and Li, {K. S.} and J. Wang and Fan, {X. H.} and Rayner, {J. M.} and D. Vijaykrishna and Zhang, {J. X.} and Zhang, {L. J.} and Guo, {C. T.} and Cheung, {C. L.} and Xu, {K. M.} and L. Duan and Kai Huang and K. Qin and Leung, {Y. H.C.} and Wu, {W. L.} and Lu, {H. R.} and Y. Chen and Xia, {N. S.} and Naipospos, {T. S.P.} and Yuen, {K. Y.} and Hassan, {S. S.} and S. Bahri and Nguyen, {T. D.} and Webster, {R. G.} and Peiris, {J. S.M.} and Y. Guan",
year = "2006",
month = "2",
day = "21",
doi = "10.1073/pnas.0511120103",
language = "English (US)",
volume = "103",
pages = "2845--2850",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "8",

}

TY - JOUR

T1 - Establishment of multiple sublineages of H5N1 influenza virus in Asia

T2 - Implications for pandemic control

AU - Chen, H.

AU - Smith, G. J.D.

AU - Li, K. S.

AU - Wang, J.

AU - Fan, X. H.

AU - Rayner, J. M.

AU - Vijaykrishna, D.

AU - Zhang, J. X.

AU - Zhang, L. J.

AU - Guo, C. T.

AU - Cheung, C. L.

AU - Xu, K. M.

AU - Duan, L.

AU - Huang, Kai

AU - Qin, K.

AU - Leung, Y. H.C.

AU - Wu, W. L.

AU - Lu, H. R.

AU - Chen, Y.

AU - Xia, N. S.

AU - Naipospos, T. S.P.

AU - Yuen, K. Y.

AU - Hassan, S. S.

AU - Bahri, S.

AU - Nguyen, T. D.

AU - Webster, R. G.

AU - Peiris, J. S.M.

AU - Guan, Y.

PY - 2006/2/21

Y1 - 2006/2/21

N2 - Preparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity.

AB - Preparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity.

KW - Avian

KW - Genetics

KW - Human

KW - Influenza A

KW - Virus evolution

UR - http://www.scopus.com/inward/record.url?scp=33644526903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644526903&partnerID=8YFLogxK

U2 - 10.1073/pnas.0511120103

DO - 10.1073/pnas.0511120103

M3 - Article

VL - 103

SP - 2845

EP - 2850

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 8

ER -