Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men

Y. E. Tsekouras, F. Magkos, S. A. Kavouras, D. B. Panagiotakos, L. S. Sidossis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Animal studies suggest that liver weight is directly related to hepatic very low-density lipoprotein-triglyceride (VLDL-TG) secretion, independently of body size. This relationship has never been examined in humans. Materials and methods: We measured VLDL-TG secretion rate by using stable isotope-labelled tracers in 21 healthy, non-obese men (age: 25 ± 3 years; body mass index: 24.8 ± 1.6 kg m-2), and evaluated the relationship between VLDL-TG secretion and indices of total and regional adiposity (body mass index, total body fat, trunk fat), metabolic parameters (free fatty acid, glucose, and insulin concentrations, homeostasis model assessment index of insulin resistance, resting energy expenditure), and estimated liver weight. Results: Correlation analysis showed that estimated liver weight was positively associated with total VLDL-TG secretion rate (r = 0.722, P < 0.001), VLDL-TG secretion rate per liter of plasma (r = 0.562, P = 0.008), VLDL-TG secretion rate per kilogram of body weight (r = 0.555, P = 0.009), and VLDL-TG secretion rate per kilogram of liver weight (r = 0.620, P = 0.003). In multiple regression analysis, estimated liver weight was the only significant predictor of VLDL-TG secretion rate regardless of units of expression, explaining 31-52% of total variance; none of the metabolic parameters and indices of body fatness entered the regression models. Conclusions: We conclude that estimated liver weight is directly related to hepatic VLDL-TG secretion rate in healthy non-obese men; this relationship is likely not mediated by interindividual variation in body size.

Original languageEnglish
Pages (from-to)656-662
Number of pages7
JournalEuropean Journal of Clinical Investigation
Volume38
Issue number9
DOIs
StatePublished - Sep 2008
Externally publishedYes

Fingerprint

Liver
Weights and Measures
Body Size
Body Mass Index
Fats
Insulin
very low density lipoprotein triglyceride
Adiposity
Nonesterified Fatty Acids
Regression analysis
Isotopes
Energy Metabolism
Insulin Resistance
Adipose Tissue
Animals
Homeostasis
Body Weight
Regression Analysis
Plasmas
Glucose

Keywords

  • Hepatic metabolism
  • Lipoprotein kinetics
  • Stable isotope tracers
  • Triacylglycerol

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men. / Tsekouras, Y. E.; Magkos, F.; Kavouras, S. A.; Panagiotakos, D. B.; Sidossis, L. S.

In: European Journal of Clinical Investigation, Vol. 38, No. 9, 09.2008, p. 656-662.

Research output: Contribution to journalArticle

Tsekouras, Y. E. ; Magkos, F. ; Kavouras, S. A. ; Panagiotakos, D. B. ; Sidossis, L. S. / Estimated liver weight is directly related to hepatic very low-density lipoprotein-triglyceride secretion rate in men. In: European Journal of Clinical Investigation. 2008 ; Vol. 38, No. 9. pp. 656-662.
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AU - Tsekouras, Y. E.

AU - Magkos, F.

AU - Kavouras, S. A.

AU - Panagiotakos, D. B.

AU - Sidossis, L. S.

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N2 - Background: Animal studies suggest that liver weight is directly related to hepatic very low-density lipoprotein-triglyceride (VLDL-TG) secretion, independently of body size. This relationship has never been examined in humans. Materials and methods: We measured VLDL-TG secretion rate by using stable isotope-labelled tracers in 21 healthy, non-obese men (age: 25 ± 3 years; body mass index: 24.8 ± 1.6 kg m-2), and evaluated the relationship between VLDL-TG secretion and indices of total and regional adiposity (body mass index, total body fat, trunk fat), metabolic parameters (free fatty acid, glucose, and insulin concentrations, homeostasis model assessment index of insulin resistance, resting energy expenditure), and estimated liver weight. Results: Correlation analysis showed that estimated liver weight was positively associated with total VLDL-TG secretion rate (r = 0.722, P < 0.001), VLDL-TG secretion rate per liter of plasma (r = 0.562, P = 0.008), VLDL-TG secretion rate per kilogram of body weight (r = 0.555, P = 0.009), and VLDL-TG secretion rate per kilogram of liver weight (r = 0.620, P = 0.003). In multiple regression analysis, estimated liver weight was the only significant predictor of VLDL-TG secretion rate regardless of units of expression, explaining 31-52% of total variance; none of the metabolic parameters and indices of body fatness entered the regression models. Conclusions: We conclude that estimated liver weight is directly related to hepatic VLDL-TG secretion rate in healthy non-obese men; this relationship is likely not mediated by interindividual variation in body size.

AB - Background: Animal studies suggest that liver weight is directly related to hepatic very low-density lipoprotein-triglyceride (VLDL-TG) secretion, independently of body size. This relationship has never been examined in humans. Materials and methods: We measured VLDL-TG secretion rate by using stable isotope-labelled tracers in 21 healthy, non-obese men (age: 25 ± 3 years; body mass index: 24.8 ± 1.6 kg m-2), and evaluated the relationship between VLDL-TG secretion and indices of total and regional adiposity (body mass index, total body fat, trunk fat), metabolic parameters (free fatty acid, glucose, and insulin concentrations, homeostasis model assessment index of insulin resistance, resting energy expenditure), and estimated liver weight. Results: Correlation analysis showed that estimated liver weight was positively associated with total VLDL-TG secretion rate (r = 0.722, P < 0.001), VLDL-TG secretion rate per liter of plasma (r = 0.562, P = 0.008), VLDL-TG secretion rate per kilogram of body weight (r = 0.555, P = 0.009), and VLDL-TG secretion rate per kilogram of liver weight (r = 0.620, P = 0.003). In multiple regression analysis, estimated liver weight was the only significant predictor of VLDL-TG secretion rate regardless of units of expression, explaining 31-52% of total variance; none of the metabolic parameters and indices of body fatness entered the regression models. Conclusions: We conclude that estimated liver weight is directly related to hepatic VLDL-TG secretion rate in healthy non-obese men; this relationship is likely not mediated by interindividual variation in body size.

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