Estimation of glomerular filtration rate in preeclamptic patients

Arnold B. Alper, Yeonjoo Yi, Larry S. Webber, Gabriella Pridjian, Abimbola Aina Mumuney, George Saade, Jamie Morgan, Bahij Nuwayhid, Michael Beifort, Jules Puschett

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Accurate estimation of the glomerular filtration rate (GFR) in patients with preeclampsia is often difficult or impossible to accomplish. In this study, the Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and MDRD2 formulas were evaluated for their accuracy in determining GFR in the setting of preeclampsia. The estimated GFR calculated from these formulas was compared with the creatinine clearance values obtained from a 24-hour urine collection in 209 preeclamptic patients recruited from five large hospitals. Additionally, a set of new equations that more accurately estimate GFR in preeclamptic patients based on ethnicity, preeclampsia GFR (PGFR), was created. Both the CG and MDRD formulas were inaccurate in predicting GFR in preeclamptic patients, and both were significantly less accurate than PGFR. In conclusion, current GFR estimation equations based on serum creatinine values in nonpregnant patients are not reliable measures of renal function in patients with preeclampsia. The use of a new (PGFR) formula is recommended.

Original languageEnglish (US)
Pages (from-to)569-574
Number of pages6
JournalAmerican Journal of Perinatology
Volume24
Issue number10
DOIs
StatePublished - Nov 2007

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Glomerular Filtration Rate
Pre-Eclampsia
Diet Therapy
Kidney
Creatinine
Urine Specimen Collection
Serum

Keywords

  • Glomerular filtration rate
  • Preeclampsia
  • Renal function

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Alper, A. B., Yi, Y., Webber, L. S., Pridjian, G., Mumuney, A. A., Saade, G., ... Puschett, J. (2007). Estimation of glomerular filtration rate in preeclamptic patients. American Journal of Perinatology, 24(10), 569-574. https://doi.org/10.1055/s-2007-986697

Estimation of glomerular filtration rate in preeclamptic patients. / Alper, Arnold B.; Yi, Yeonjoo; Webber, Larry S.; Pridjian, Gabriella; Mumuney, Abimbola Aina; Saade, George; Morgan, Jamie; Nuwayhid, Bahij; Beifort, Michael; Puschett, Jules.

In: American Journal of Perinatology, Vol. 24, No. 10, 11.2007, p. 569-574.

Research output: Contribution to journalArticle

Alper, AB, Yi, Y, Webber, LS, Pridjian, G, Mumuney, AA, Saade, G, Morgan, J, Nuwayhid, B, Beifort, M & Puschett, J 2007, 'Estimation of glomerular filtration rate in preeclamptic patients', American Journal of Perinatology, vol. 24, no. 10, pp. 569-574. https://doi.org/10.1055/s-2007-986697
Alper, Arnold B. ; Yi, Yeonjoo ; Webber, Larry S. ; Pridjian, Gabriella ; Mumuney, Abimbola Aina ; Saade, George ; Morgan, Jamie ; Nuwayhid, Bahij ; Beifort, Michael ; Puschett, Jules. / Estimation of glomerular filtration rate in preeclamptic patients. In: American Journal of Perinatology. 2007 ; Vol. 24, No. 10. pp. 569-574.
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