Estimation of glomerular filtration rate in preeclamptic patients

Arnold B. Alper, Yeonjoo Yi, Larry S. Webber, Gabriella Pridjian, Abimbola Aina Mumuney, George Saade, Jamie Morgan, Bahij Nuwayhid, Michael Beifort, Jules Puschett

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Accurate estimation of the glomerular filtration rate (GFR) in patients with preeclampsia is often difficult or impossible to accomplish. In this study, the Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and MDRD2 formulas were evaluated for their accuracy in determining GFR in the setting of preeclampsia. The estimated GFR calculated from these formulas was compared with the creatinine clearance values obtained from a 24-hour urine collection in 209 preeclamptic patients recruited from five large hospitals. Additionally, a set of new equations that more accurately estimate GFR in preeclamptic patients based on ethnicity, preeclampsia GFR (PGFR), was created. Both the CG and MDRD formulas were inaccurate in predicting GFR in preeclamptic patients, and both were significantly less accurate than PGFR. In conclusion, current GFR estimation equations based on serum creatinine values in nonpregnant patients are not reliable measures of renal function in patients with preeclampsia. The use of a new (PGFR) formula is recommended.

Original languageEnglish (US)
Pages (from-to)569-574
Number of pages6
JournalAmerican Journal of Perinatology
Volume24
Issue number10
DOIs
StatePublished - Nov 1 2007

Keywords

  • Glomerular filtration rate
  • Preeclampsia
  • Renal function

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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    Alper, A. B., Yi, Y., Webber, L. S., Pridjian, G., Mumuney, A. A., Saade, G., Morgan, J., Nuwayhid, B., Beifort, M., & Puschett, J. (2007). Estimation of glomerular filtration rate in preeclamptic patients. American Journal of Perinatology, 24(10), 569-574. https://doi.org/10.1055/s-2007-986697