TY - JOUR
T1 - Estimation of glomerular filtration rate in preeclamptic patients
AU - Alper, Arnold B.
AU - Yi, Yeonjoo
AU - Webber, Larry S.
AU - Pridjian, Gabriella
AU - Mumuney, Abimbola Aina
AU - Saade, George
AU - Morgan, Jamie
AU - Nuwayhid, Bahij
AU - Beifort, Michael
AU - Puschett, Jules
PY - 2007/11
Y1 - 2007/11
N2 - Accurate estimation of the glomerular filtration rate (GFR) in patients with preeclampsia is often difficult or impossible to accomplish. In this study, the Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and MDRD2 formulas were evaluated for their accuracy in determining GFR in the setting of preeclampsia. The estimated GFR calculated from these formulas was compared with the creatinine clearance values obtained from a 24-hour urine collection in 209 preeclamptic patients recruited from five large hospitals. Additionally, a set of new equations that more accurately estimate GFR in preeclamptic patients based on ethnicity, preeclampsia GFR (PGFR), was created. Both the CG and MDRD formulas were inaccurate in predicting GFR in preeclamptic patients, and both were significantly less accurate than PGFR. In conclusion, current GFR estimation equations based on serum creatinine values in nonpregnant patients are not reliable measures of renal function in patients with preeclampsia. The use of a new (PGFR) formula is recommended.
AB - Accurate estimation of the glomerular filtration rate (GFR) in patients with preeclampsia is often difficult or impossible to accomplish. In this study, the Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), and MDRD2 formulas were evaluated for their accuracy in determining GFR in the setting of preeclampsia. The estimated GFR calculated from these formulas was compared with the creatinine clearance values obtained from a 24-hour urine collection in 209 preeclamptic patients recruited from five large hospitals. Additionally, a set of new equations that more accurately estimate GFR in preeclamptic patients based on ethnicity, preeclampsia GFR (PGFR), was created. Both the CG and MDRD formulas were inaccurate in predicting GFR in preeclamptic patients, and both were significantly less accurate than PGFR. In conclusion, current GFR estimation equations based on serum creatinine values in nonpregnant patients are not reliable measures of renal function in patients with preeclampsia. The use of a new (PGFR) formula is recommended.
KW - Glomerular filtration rate
KW - Preeclampsia
KW - Renal function
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U2 - 10.1055/s-2007-986697
DO - 10.1055/s-2007-986697
M3 - Article
C2 - 17909992
AN - SCOPUS:36448955703
SN - 0735-1631
VL - 24
SP - 569
EP - 574
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 10
ER -