Estimation of regional left ventricular wall stresses in intact canine hearts

Abelardo DeAnda, Masashi Komeda, Marc R. Moon, G. Randall Green, Ann F. Bolger, Srdjan D. Nikolic, George T. Daughters, D. Craig Miller

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Left ventricular (LV) wall stress is an important element in the assessment of LV systolic function; however, a reproducible technique to determine instantaneous local or regional wall stress has not been developed. Fourteen dogs underwent placement of twenty-six myocardial markers into the ventricle and septum. One week later, marker images were obtained using high-speed biplane videofluoroscopy under awake, sedated, atrially paced baseline conditions and after inotropic stimulation (calcium). With a model taking into account LV pressure, regional wall thickness, and meridional and circumferential regional radii of curvature, we computed average midwall stress for each of nine LV sites. Regional end-systolic and maximal LV wall stress were heterogeneous and dependent on latitude (increasing from apex to base, P <0.001) and specific wall (anterior > lateral and posterior wall stresses; P = 0.002). Multivariate ANOVA demonstrated only a trend (P = 0.056) toward increased LV stress after calcium infusion; subsequent univariate analysis isolated significant increases in end-systolic LV wall stress with increased inotropic state at all sites except the equatorial regions. The model used in this analysis incorporates local geometric factors and provides a reasonable estimate of regional LV wall stress compared with previous studies. LV wall stress is heterogeneous and dependent on the particular LV site of interest. Variation in wall stress may be caused by anatomic differences and/or extrinsic interactions between LV sites, i.e., influences of the papillary muscles and the interventricular septum.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume44
Issue number5
StatePublished - Nov 1998
Externally publishedYes

Fingerprint

Canidae
Calcium
Papillary Muscles
Ventricular Pressure
Left Ventricular Function
Analysis of Variance
Dogs
6H,8H-3,4-dihydropyrimido(4,5-c)(1,2)oxazin-7-one

Keywords

  • Systolic function

ASJC Scopus subject areas

  • Physiology

Cite this

DeAnda, A., Komeda, M., Moon, M. R., Green, G. R., Bolger, A. F., Nikolic, S. D., ... Miller, D. C. (1998). Estimation of regional left ventricular wall stresses in intact canine hearts. American Journal of Physiology - Heart and Circulatory Physiology, 44(5).

Estimation of regional left ventricular wall stresses in intact canine hearts. / DeAnda, Abelardo; Komeda, Masashi; Moon, Marc R.; Green, G. Randall; Bolger, Ann F.; Nikolic, Srdjan D.; Daughters, George T.; Miller, D. Craig.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 44, No. 5, 11.1998.

Research output: Contribution to journalArticle

DeAnda, A, Komeda, M, Moon, MR, Green, GR, Bolger, AF, Nikolic, SD, Daughters, GT & Miller, DC 1998, 'Estimation of regional left ventricular wall stresses in intact canine hearts', American Journal of Physiology - Heart and Circulatory Physiology, vol. 44, no. 5.
DeAnda, Abelardo ; Komeda, Masashi ; Moon, Marc R. ; Green, G. Randall ; Bolger, Ann F. ; Nikolic, Srdjan D. ; Daughters, George T. ; Miller, D. Craig. / Estimation of regional left ventricular wall stresses in intact canine hearts. In: American Journal of Physiology - Heart and Circulatory Physiology. 1998 ; Vol. 44, No. 5.
@article{e380f12839c040df8d3f93f98fbe4295,
title = "Estimation of regional left ventricular wall stresses in intact canine hearts",
abstract = "Left ventricular (LV) wall stress is an important element in the assessment of LV systolic function; however, a reproducible technique to determine instantaneous local or regional wall stress has not been developed. Fourteen dogs underwent placement of twenty-six myocardial markers into the ventricle and septum. One week later, marker images were obtained using high-speed biplane videofluoroscopy under awake, sedated, atrially paced baseline conditions and after inotropic stimulation (calcium). With a model taking into account LV pressure, regional wall thickness, and meridional and circumferential regional radii of curvature, we computed average midwall stress for each of nine LV sites. Regional end-systolic and maximal LV wall stress were heterogeneous and dependent on latitude (increasing from apex to base, P <0.001) and specific wall (anterior > lateral and posterior wall stresses; P = 0.002). Multivariate ANOVA demonstrated only a trend (P = 0.056) toward increased LV stress after calcium infusion; subsequent univariate analysis isolated significant increases in end-systolic LV wall stress with increased inotropic state at all sites except the equatorial regions. The model used in this analysis incorporates local geometric factors and provides a reasonable estimate of regional LV wall stress compared with previous studies. LV wall stress is heterogeneous and dependent on the particular LV site of interest. Variation in wall stress may be caused by anatomic differences and/or extrinsic interactions between LV sites, i.e., influences of the papillary muscles and the interventricular septum.",
keywords = "Systolic function",
author = "Abelardo DeAnda and Masashi Komeda and Moon, {Marc R.} and Green, {G. Randall} and Bolger, {Ann F.} and Nikolic, {Srdjan D.} and Daughters, {George T.} and Miller, {D. Craig}",
year = "1998",
month = "11",
language = "English (US)",
volume = "44",
journal = "American Journal of Physiology - Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Estimation of regional left ventricular wall stresses in intact canine hearts

AU - DeAnda, Abelardo

AU - Komeda, Masashi

AU - Moon, Marc R.

AU - Green, G. Randall

AU - Bolger, Ann F.

AU - Nikolic, Srdjan D.

AU - Daughters, George T.

AU - Miller, D. Craig

PY - 1998/11

Y1 - 1998/11

N2 - Left ventricular (LV) wall stress is an important element in the assessment of LV systolic function; however, a reproducible technique to determine instantaneous local or regional wall stress has not been developed. Fourteen dogs underwent placement of twenty-six myocardial markers into the ventricle and septum. One week later, marker images were obtained using high-speed biplane videofluoroscopy under awake, sedated, atrially paced baseline conditions and after inotropic stimulation (calcium). With a model taking into account LV pressure, regional wall thickness, and meridional and circumferential regional radii of curvature, we computed average midwall stress for each of nine LV sites. Regional end-systolic and maximal LV wall stress were heterogeneous and dependent on latitude (increasing from apex to base, P <0.001) and specific wall (anterior > lateral and posterior wall stresses; P = 0.002). Multivariate ANOVA demonstrated only a trend (P = 0.056) toward increased LV stress after calcium infusion; subsequent univariate analysis isolated significant increases in end-systolic LV wall stress with increased inotropic state at all sites except the equatorial regions. The model used in this analysis incorporates local geometric factors and provides a reasonable estimate of regional LV wall stress compared with previous studies. LV wall stress is heterogeneous and dependent on the particular LV site of interest. Variation in wall stress may be caused by anatomic differences and/or extrinsic interactions between LV sites, i.e., influences of the papillary muscles and the interventricular septum.

AB - Left ventricular (LV) wall stress is an important element in the assessment of LV systolic function; however, a reproducible technique to determine instantaneous local or regional wall stress has not been developed. Fourteen dogs underwent placement of twenty-six myocardial markers into the ventricle and septum. One week later, marker images were obtained using high-speed biplane videofluoroscopy under awake, sedated, atrially paced baseline conditions and after inotropic stimulation (calcium). With a model taking into account LV pressure, regional wall thickness, and meridional and circumferential regional radii of curvature, we computed average midwall stress for each of nine LV sites. Regional end-systolic and maximal LV wall stress were heterogeneous and dependent on latitude (increasing from apex to base, P <0.001) and specific wall (anterior > lateral and posterior wall stresses; P = 0.002). Multivariate ANOVA demonstrated only a trend (P = 0.056) toward increased LV stress after calcium infusion; subsequent univariate analysis isolated significant increases in end-systolic LV wall stress with increased inotropic state at all sites except the equatorial regions. The model used in this analysis incorporates local geometric factors and provides a reasonable estimate of regional LV wall stress compared with previous studies. LV wall stress is heterogeneous and dependent on the particular LV site of interest. Variation in wall stress may be caused by anatomic differences and/or extrinsic interactions between LV sites, i.e., influences of the papillary muscles and the interventricular septum.

KW - Systolic function

UR - http://www.scopus.com/inward/record.url?scp=33750690741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750690741&partnerID=8YFLogxK

M3 - Article

C2 - 9815097

AN - SCOPUS:0031751671

VL - 44

JO - American Journal of Physiology - Endocrinology and Metabolism

JF - American Journal of Physiology - Endocrinology and Metabolism

SN - 0193-1849

IS - 5

ER -