Estrogen effects on the hyperactivity induced by (+)-MDMA and cocaine in female rats

Wenxia Zhou, Kathryn A. Cunningham, Mary L. Thomas

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


This study compared the effects of estrogen (E) on the hyperactivity induced by (+)-3,4-methylenedioxymethamphetamine (MDMA) with E effects on cocaine-evoked hyperactivity in female rats. Sprague-Dawley rats were ovariectomized (OVX); half of them received a 17β-estradiol (E2) implant (OVX + E). Three weeks later, rats received saline, (+)-MDMA (1, 2, or 4 mg/kg) or cocaine (5, 10, or 20 mg/kg), and locomotor activity was monitored. OVX + E rats exhibited greater locomotor hyperactivity in response to both psychostimulants than did OVX rats. The enhanced response to cocaine appeared within 5 min following drug injection whereas the enhanced response to (+)-MDMA was delayed for approximately 30 min. The differential effects of E on hyperactivity may be due to the unique profiles of DA and 5-HT in response to (+)-MDMA and cocaine.

Original languageEnglish (US)
Pages (from-to)84-94
Number of pages11
JournalBehavioral neuroscience
Issue number1
StatePublished - Feb 2003

ASJC Scopus subject areas

  • Behavioral Neuroscience


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