Estrogenic effects of nafoxidine on ovarian-dependent and independent mammary tumor lines in the mouse

C. S. Watson, D. Medina, J. H. Clark

Research output: Contribution to journalArticle

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Abstract

Nafoxidine (1-[2-[p-(3,4-dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy]ethyl]-pyrrolidi ne hydrochloride); a triphenylethylene derivative] and estradiol cause translocation of the estrogen receptor to the nucleus, elevate the levels of cytoplasmic progesterone receptors, and do not affect levels of nuclear progesterone receptor in hormone-dependent and independent MXT-3590 mammary tumor lines. Cytoplasmic and nuclear receptor levels were measured by the dextran-coated charcoal assay and a modified protamine sulfate nuclear exchange assay, respectively. Both estradiol (2.5 μg) and nafoxidine (40 μg) stimulate partial growth in the independent line. These data are the first evidence of the estrogenic effects of a so-called antiestrogen (nafoxidine) on the quantity of progesterone receptors in a hormone-independent experimental mammary tumor. The growth effects of antiestrogens demonstrated here in ovariectomized mice should alert clinicians to be watchful of these effects when using such drugs in the treatment of human breast cancer. These results also confirm recent suggestions that growth and progesterone receptor synthesis are controlled separately by estrogenic compounds.

Original languageEnglish (US)
Pages (from-to)668-672
Number of pages5
JournalEndocrinology
Volume108
Issue number2
StatePublished - 1981
Externally publishedYes

Fingerprint

Nafoxidine
Progesterone Receptors
Estrogens
Cytoplasmic and Nuclear Receptors
Breast Neoplasms
Estrogen Receptor Modulators
Estradiol
Growth
Hormones
Protamines
Charcoal
Dextrans
Estrogen Receptors
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Estrogenic effects of nafoxidine on ovarian-dependent and independent mammary tumor lines in the mouse. / Watson, C. S.; Medina, D.; Clark, J. H.

In: Endocrinology, Vol. 108, No. 2, 1981, p. 668-672.

Research output: Contribution to journalArticle

Watson, C. S. ; Medina, D. ; Clark, J. H. / Estrogenic effects of nafoxidine on ovarian-dependent and independent mammary tumor lines in the mouse. In: Endocrinology. 1981 ; Vol. 108, No. 2. pp. 668-672.
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