Estrogens and surgery in women with von Willebrand's disease

J. B. Alperin

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


While receiving estrogen therapy, three women with classic type I von Willebrand's disease showed significantly less bleeding and improved hemostasis. One took estrogens to prevent menopausal symptoms, and two used oral contraceptives. These women underwent major surgery without excessive bleeding and without requiring cryoprecipitate or other blood components. Prior to estrogen therapy, each women had received cryoprecipitate of fresh frozen plasma to stop bleeding from dental extractions or other surgical procedures. Furthermore, two other women with type I von Willebrand's disease also exhibited improved hemostasis while taking oral contraceptives. These experiences suggest a short course of estrogen therapy may effectively prepare some women with von Willebrand's disease for elective surgery.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalAmerican Journal of Medicine
Issue number3
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Medicine(all)


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