Abstract
While receiving estrogen therapy, three women with classic type I von Willebrand's disease showed significantly less bleeding and improved hemostasis. One took estrogens to prevent menopausal symptoms, and two used oral contraceptives. These women underwent major surgery without excessive bleeding and without requiring cryoprecipitate or other blood components. Prior to estrogen therapy, each woman had received cryoprecipitate or fresh frozen plasma to stop bleeding from dental extractions or other surgical procedures. Furthermore, two other women with type I von Willebrand's disease also exhibited improved hemostasis while taking oral contraceptives. These experiences suggest a short course of estrogen therapy may effectively prepare some women with von Willebrand's disease for elective surgery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 322-327 |
| Number of pages | 6 |
| Journal | The American Journal of Medicine |
| Volume | 73 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1982 |
| Externally published | Yes |
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Cite this
Estrogens and surgery in women with von Willebrand's disease. / Alperin, Jack B.
In: The American Journal of Medicine, Vol. 73, No. 3, 1982, p. 322-327.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Estrogens and surgery in women with von Willebrand's disease
AU - Alperin, Jack B.
PY - 1982
Y1 - 1982
N2 - While receiving estrogen therapy, three women with classic type I von Willebrand's disease showed significantly less bleeding and improved hemostasis. One took estrogens to prevent menopausal symptoms, and two used oral contraceptives. These women underwent major surgery without excessive bleeding and without requiring cryoprecipitate or other blood components. Prior to estrogen therapy, each woman had received cryoprecipitate or fresh frozen plasma to stop bleeding from dental extractions or other surgical procedures. Furthermore, two other women with type I von Willebrand's disease also exhibited improved hemostasis while taking oral contraceptives. These experiences suggest a short course of estrogen therapy may effectively prepare some women with von Willebrand's disease for elective surgery.
AB - While receiving estrogen therapy, three women with classic type I von Willebrand's disease showed significantly less bleeding and improved hemostasis. One took estrogens to prevent menopausal symptoms, and two used oral contraceptives. These women underwent major surgery without excessive bleeding and without requiring cryoprecipitate or other blood components. Prior to estrogen therapy, each woman had received cryoprecipitate or fresh frozen plasma to stop bleeding from dental extractions or other surgical procedures. Furthermore, two other women with type I von Willebrand's disease also exhibited improved hemostasis while taking oral contraceptives. These experiences suggest a short course of estrogen therapy may effectively prepare some women with von Willebrand's disease for elective surgery.
UR - http://www.scopus.com/inward/record.url?scp=49049139372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49049139372&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(82)90717-3
DO - 10.1016/0002-9343(82)90717-3
M3 - Article
VL - 73
SP - 322
EP - 327
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 3
ER -