Ethanol enhancement of the motor-stimulating effect of nicotine in the rat

E. P. Lapin, H. S. Maker, A. Bhardwaj

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Although ethanol stimulates locomotion in mice, it has been difficult to demonstrate such an action in rats. In contrast, nicotine has been shown to enhance locomotion, including ipsiversive rotation in nigral-lesioned rats. We found no significant effect of ethanol alone on rat rotation at doses of 0.125, 0.50, 1.0, and 2.0 g/kg, IP, during a 30-min observation period. However, there was a dose-dependent effect of ethanol enhancing the rotation induced by nicotine (0.4 mg/kg, SC) given 30 min after the ethanol. The interaction of ethanol and nicotine on locomotion most likely involves the release of dopamine and may be related to the motor abnormalities sometimes seen clinically.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
Issue number3
StatePublished - Jan 1 1995
Externally publishedYes


  • Ethanol enhancement of nicotine
  • Lesions of the substantia nigra
  • Nicotine-ethanol interaction
  • Nicotine-induced rotation

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience


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