Ethanol impairs post-prandial hepatic protein metabolism

Pierpaolo De Feo, Elena Volpi, Paola Lucidi, Guido Cruciani, Francesca Monacchia, Gianpaolo Reboldi, Fausto Santeusanio, Geremia B. Bolli, Paolo Brunetti

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The effects of acute ethanol ingestion on whole body and hepatic protein metabolism in humans are not known. To simulate social drinking, we compared the effects of the association of a mixed meal (632 kcal, 17% amino acids, 50% glucose, 33% lipids) with a bottle of either table wine (ethanol content 71 g) or water on the estimates ([1-14C]-leucine infusion) of whole body protein breakdown, oxidation, and synthesis, and on the intravascular fractional secretory rates (FSR) of hepatically (albumin, fibrinogen) and extrahepatically (IgG) synthesized plasma proteins in two randomized groups (ethanol n = 7, water n = 7) of healthy nonalcoholic volunteers. Each study was carried out for 8 h. Protein kinetics were measured in the overnight post-absorptive state, over the first 4 h, and during a meal infusion (via a nasogastric feeding tube at constant rate) combined with the oral ingestion of wine or water, over the last 4 h. When compared with water, wine ingestion during the meal reduced (P < 0.03) by 24% the rate of leucine oxidation, did not modify the estimates of whole body protein breakdown and synthesis, reduced (P < 0.01) by ~ 30% the FSR of albumin and fibrinogen, but did not affect igG FSR. In conclusion, 70 g of ethanol, an amount usual among social drinkers, impairs hepatic protein metabolism. The habitual consumption of such amounts by reducing the synthesis and/or secretion of hepatic proteins might lead to the progressive development of liver injury and to hypoalbuminemia also in the absence of protein malnutrition.

Original languageEnglish (US)
Pages (from-to)1472-1479
Number of pages8
JournalJournal of Clinical Investigation
Volume95
Issue number4
StatePublished - Apr 1995
Externally publishedYes

Fingerprint

Meals
Ethanol
Secretory Rate
Liver
Wine
Proteins
Water
Eating
Leucine
Fibrinogen
Albumins
Hypoalbuminemia
Enteral Nutrition
Malnutrition
Drinking
Blood Proteins
Healthy Volunteers
Immunoglobulin G
Lipids
Amino Acids

Keywords

  • albumin
  • alcohol
  • fibrinogen
  • immunoglobulins
  • leucine metabolism

ASJC Scopus subject areas

  • Medicine(all)

Cite this

De Feo, P., Volpi, E., Lucidi, P., Cruciani, G., Monacchia, F., Reboldi, G., ... Brunetti, P. (1995). Ethanol impairs post-prandial hepatic protein metabolism. Journal of Clinical Investigation, 95(4), 1472-1479.

Ethanol impairs post-prandial hepatic protein metabolism. / De Feo, Pierpaolo; Volpi, Elena; Lucidi, Paola; Cruciani, Guido; Monacchia, Francesca; Reboldi, Gianpaolo; Santeusanio, Fausto; Bolli, Geremia B.; Brunetti, Paolo.

In: Journal of Clinical Investigation, Vol. 95, No. 4, 04.1995, p. 1472-1479.

Research output: Contribution to journalArticle

De Feo, P, Volpi, E, Lucidi, P, Cruciani, G, Monacchia, F, Reboldi, G, Santeusanio, F, Bolli, GB & Brunetti, P 1995, 'Ethanol impairs post-prandial hepatic protein metabolism', Journal of Clinical Investigation, vol. 95, no. 4, pp. 1472-1479.
De Feo P, Volpi E, Lucidi P, Cruciani G, Monacchia F, Reboldi G et al. Ethanol impairs post-prandial hepatic protein metabolism. Journal of Clinical Investigation. 1995 Apr;95(4):1472-1479.
De Feo, Pierpaolo ; Volpi, Elena ; Lucidi, Paola ; Cruciani, Guido ; Monacchia, Francesca ; Reboldi, Gianpaolo ; Santeusanio, Fausto ; Bolli, Geremia B. ; Brunetti, Paolo. / Ethanol impairs post-prandial hepatic protein metabolism. In: Journal of Clinical Investigation. 1995 ; Vol. 95, No. 4. pp. 1472-1479.
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AU - Santeusanio, Fausto

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