Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain

Gerald A. Campbell; Michael J. Eckardt; Edward Majchrowicz; Cheryl A. Marietta; Forrest F. Weight

doi:10.1016/0006-8993(82)90465-6

Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain

Gerald A. Campbell
, Michael J. Eckardt
, Edward Majchrowicz
, Cheryl A. Marietta
, Forrest F. Weight

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Glucose uptake was studied in the brains of rats undergoing an overt ethanol-withdrawal syndrome by 2-deoxy-d-[¹⁴C]glucose autoradiography. In addition to a general increase in glucose uptake, localized alterations were observed in sensorimotor cortex, globus pallidus, thalamus and cerebellum. The results suggest that the ethanol-withdrawal syndrome is associated with a general increase in glucose metabolism as well as localized increases in functionally distinct regions of sensory and motor brain regions.

Original language	English (US)
Pages (from-to)	517-522
Number of pages	6
Journal	Brain Research
Volume	237
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(82)90465-6
State	Published - Apr 15 1982
Externally published	Yes

Keywords

2-deoxyglucose
ethanol-withdrawal syndrome

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(82)90465-6

Cite this

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title = "Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain",

abstract = "Glucose uptake was studied in the brains of rats undergoing an overt ethanol-withdrawal syndrome by 2-deoxy-d-[14C]glucose autoradiography. In addition to a general increase in glucose uptake, localized alterations were observed in sensorimotor cortex, globus pallidus, thalamus and cerebellum. The results suggest that the ethanol-withdrawal syndrome is associated with a general increase in glucose metabolism as well as localized increases in functionally distinct regions of sensory and motor brain regions.",

keywords = "2-deoxyglucose, ethanol-withdrawal syndrome",

author = "Campbell, \{Gerald A.\} and Eckardt, \{Michael J.\} and Edward Majchrowicz and Marietta, \{Cheryl A.\} and Weight, \{Forrest F.\}",

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doi = "10.1016/0006-8993(82)90465-6",

language = "English (US)",

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T1 - Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain

AU - Campbell, Gerald A.

AU - Eckardt, Michael J.

AU - Majchrowicz, Edward

AU - Marietta, Cheryl A.

AU - Weight, Forrest F.

PY - 1982/4/15

Y1 - 1982/4/15

N2 - Glucose uptake was studied in the brains of rats undergoing an overt ethanol-withdrawal syndrome by 2-deoxy-d-[14C]glucose autoradiography. In addition to a general increase in glucose uptake, localized alterations were observed in sensorimotor cortex, globus pallidus, thalamus and cerebellum. The results suggest that the ethanol-withdrawal syndrome is associated with a general increase in glucose metabolism as well as localized increases in functionally distinct regions of sensory and motor brain regions.

AB - Glucose uptake was studied in the brains of rats undergoing an overt ethanol-withdrawal syndrome by 2-deoxy-d-[14C]glucose autoradiography. In addition to a general increase in glucose uptake, localized alterations were observed in sensorimotor cortex, globus pallidus, thalamus and cerebellum. The results suggest that the ethanol-withdrawal syndrome is associated with a general increase in glucose metabolism as well as localized increases in functionally distinct regions of sensory and motor brain regions.

KW - 2-deoxyglucose

KW - ethanol-withdrawal syndrome

UR - https://www.scopus.com/pages/publications/0020025143

UR - https://www.scopus.com/pages/publications/0020025143#tab=citedBy

U2 - 10.1016/0006-8993(82)90465-6

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AN - SCOPUS:0020025143

SN - 0006-8993

VL - 237

SP - 517

EP - 522

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Ethanol-withdrawal syndrome associated with both general and localized increases in glucose uptake in rat brain

Abstract

Keywords

ASJC Scopus subject areas

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