Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort

Manisha Chandalia, Scott M. Grundy, Beverley Adams-Huet, Nicola Abate

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Genetic susceptibility modulates the impact of obesity on the risk for type 2 diabetes. One candidate gene predisposing to type 2 diabetes is ENPP1/PC1. A common polymorphism in this protein, K121Q, is associated with insulin resistance and increased susceptibility to type 2 diabetes in Caucasian, Afro-Caribbean, and South Asian populations. The goal of this study was to evaluate differences in the prevalence of the ENPP1 121Q variant in the Caucasian, African-American, and Hispanic populations in Dallas county and to establish a population-based estimate of gene variant prevalence for future investigations. We also evaluated the association between the ENPP1 121Q variant and diabetes. The Dallas Heart Study (DHS) is a multiethnic probability-based sample of the Dallas county population in which African-Americans were systematically oversampled so that the final sample was 50% African-Americans. We performed ENPP1/PC1 genotyping in 1038 non-Hispanic Whites (544 women, 494 men), 1815 African-Americans (1052 women and 763 men), and 597 Hispanics (347 women, 250 men). The frequency of ENPP1/PC1 K121Q was higher in both African-Americans (78.5%) and Hispanics (21.9%) than in the non-Hispanic White group (13.2%). The former two groups also have a higher prevalence of type 2 diabetes (African-Americans, 14.1%, and Hispanics, 11.7%) compared to non-Hispanic Whites (6.8%). Logistic regression analysis revealed significant interactions between the ENPP1 genotype, age, and body mass index within each ethnic group. After adjustment for these variables and their interactions, ENPP1 Q allele predicted diabetes when a recessive model was tested. Ethnic differences in ENPP1 121Q allele frequency may contribute to the increased susceptibility to type 2 diabetes observed in US minority groups.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalJournal of Diabetes and its Complications
Volume21
Issue number3
DOIs
StatePublished - May 2007
Externally publishedYes

Fingerprint

African Americans
Cohort Studies
Type 2 Diabetes Mellitus
Hispanic Americans
Population
Minority Groups
Sampling Studies
Genetic Predisposition to Disease
Ethnic Groups
Gene Frequency
Genes
Insulin Resistance
Body Mass Index
Obesity
Logistic Models
Alleles
Genotype
Regression Analysis
Proteins

Keywords

  • ENPP1
  • Ethnicity
  • Insulin resistance
  • PC-1
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort. / Chandalia, Manisha; Grundy, Scott M.; Adams-Huet, Beverley; Abate, Nicola.

In: Journal of Diabetes and its Complications, Vol. 21, No. 3, 05.2007, p. 143-148.

Research output: Contribution to journalArticle

Chandalia, Manisha ; Grundy, Scott M. ; Adams-Huet, Beverley ; Abate, Nicola. / Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort. In: Journal of Diabetes and its Complications. 2007 ; Vol. 21, No. 3. pp. 143-148.
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abstract = "Genetic susceptibility modulates the impact of obesity on the risk for type 2 diabetes. One candidate gene predisposing to type 2 diabetes is ENPP1/PC1. A common polymorphism in this protein, K121Q, is associated with insulin resistance and increased susceptibility to type 2 diabetes in Caucasian, Afro-Caribbean, and South Asian populations. The goal of this study was to evaluate differences in the prevalence of the ENPP1 121Q variant in the Caucasian, African-American, and Hispanic populations in Dallas county and to establish a population-based estimate of gene variant prevalence for future investigations. We also evaluated the association between the ENPP1 121Q variant and diabetes. The Dallas Heart Study (DHS) is a multiethnic probability-based sample of the Dallas county population in which African-Americans were systematically oversampled so that the final sample was 50{\%} African-Americans. We performed ENPP1/PC1 genotyping in 1038 non-Hispanic Whites (544 women, 494 men), 1815 African-Americans (1052 women and 763 men), and 597 Hispanics (347 women, 250 men). The frequency of ENPP1/PC1 K121Q was higher in both African-Americans (78.5{\%}) and Hispanics (21.9{\%}) than in the non-Hispanic White group (13.2{\%}). The former two groups also have a higher prevalence of type 2 diabetes (African-Americans, 14.1{\%}, and Hispanics, 11.7{\%}) compared to non-Hispanic Whites (6.8{\%}). Logistic regression analysis revealed significant interactions between the ENPP1 genotype, age, and body mass index within each ethnic group. After adjustment for these variables and their interactions, ENPP1 Q allele predicted diabetes when a recessive model was tested. Ethnic differences in ENPP1 121Q allele frequency may contribute to the increased susceptibility to type 2 diabetes observed in US minority groups.",
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