Ethnic disparity in spontaneous preterm birth and maternal pre-pregnancy body mass index

Maria Regina Torloni, Stephen J. Fortunato, Ana Pilar Betrán, Scott Williams, Lina Brou, Cayce Owens Drobek, Mario Merialdi, Ramkumar Menon

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose To investigate differences in pre-pregnancy BMI status in patients with spontaneous preterm birth (PTB) compared with term birth and assess the role of ethnicity as a risk modifier in BMI-associated PTB. Methods A case-control study involving self-reported African American and Caucasian women delivering singletons in Nashville, TN, USA, 2003-2009. Maternal prepregnancy BMI was recorded in 447 PTB-cases (African American = 145, Caucasian = 302) and 1315 term-birth controls (African American = 522; Caucasian = 793). Crude and adjusted odds ratio (OR and AOR) for PTB were calculated using normal BMI (18.5-24.9 kg/m2) as reference. Age, education, marital status, income, smoking, parity, previous PTB and pregnancy weight gain were included as covariates in logistic regression. Results No significant differences were noted in the OR for PTB among different BMI categories when women of different ethnicity were combined. Odds of PTB were greater in obese than in normal weight Caucasian women, even after adjusting for confounders (AOR = 1.84, 95%CI [1.15, 2.95]). Obese African American women had a decreased crude OR for PTB, although this was not significant after adjusting for confounders (AOR = 0.72, 95%CI [0.38, 1.40]). The odds for early PTB (\32 weeks) were decreased in obese compared with normal weight African American women (OR = 0.23, 95%CI [0.08, 0.70]), whereas they were increased in obese compared with normal weight Caucasian women (OR = 2.30, 95%CI [1.32, 4.00]). Conclusion The risk for PTB in women with different prepregnancy BMI categories differs according to ethnicity.

Original languageEnglish (US)
Pages (from-to)959-966
Number of pages8
JournalArchives of Gynecology and Obstetrics
Volume285
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

Premature Birth
Body Mass Index
Mothers
Pregnancy
African Americans
Term Birth
Weights and Measures
Marital Status
Parity
Contraception
Birth Weight
Weight Gain
Case-Control Studies
Logistic Models
Smoking
Odds Ratio
Education

Keywords

  • African Americans
  • Body mass index
  • Ethnic groups
  • European continental ancestry group
  • Nutrition
  • Premature birth

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Ethnic disparity in spontaneous preterm birth and maternal pre-pregnancy body mass index. / Torloni, Maria Regina; Fortunato, Stephen J.; Betrán, Ana Pilar; Williams, Scott; Brou, Lina; Drobek, Cayce Owens; Merialdi, Mario; Menon, Ramkumar.

In: Archives of Gynecology and Obstetrics, Vol. 285, No. 4, 04.2012, p. 959-966.

Research output: Contribution to journalArticle

Torloni, MR, Fortunato, SJ, Betrán, AP, Williams, S, Brou, L, Drobek, CO, Merialdi, M & Menon, R 2012, 'Ethnic disparity in spontaneous preterm birth and maternal pre-pregnancy body mass index', Archives of Gynecology and Obstetrics, vol. 285, no. 4, pp. 959-966. https://doi.org/10.1007/s00404-011-2102-8
Torloni, Maria Regina ; Fortunato, Stephen J. ; Betrán, Ana Pilar ; Williams, Scott ; Brou, Lina ; Drobek, Cayce Owens ; Merialdi, Mario ; Menon, Ramkumar. / Ethnic disparity in spontaneous preterm birth and maternal pre-pregnancy body mass index. In: Archives of Gynecology and Obstetrics. 2012 ; Vol. 285, No. 4. pp. 959-966.
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abstract = "Purpose To investigate differences in pre-pregnancy BMI status in patients with spontaneous preterm birth (PTB) compared with term birth and assess the role of ethnicity as a risk modifier in BMI-associated PTB. Methods A case-control study involving self-reported African American and Caucasian women delivering singletons in Nashville, TN, USA, 2003-2009. Maternal prepregnancy BMI was recorded in 447 PTB-cases (African American = 145, Caucasian = 302) and 1315 term-birth controls (African American = 522; Caucasian = 793). Crude and adjusted odds ratio (OR and AOR) for PTB were calculated using normal BMI (18.5-24.9 kg/m2) as reference. Age, education, marital status, income, smoking, parity, previous PTB and pregnancy weight gain were included as covariates in logistic regression. Results No significant differences were noted in the OR for PTB among different BMI categories when women of different ethnicity were combined. Odds of PTB were greater in obese than in normal weight Caucasian women, even after adjusting for confounders (AOR = 1.84, 95{\%}CI [1.15, 2.95]). Obese African American women had a decreased crude OR for PTB, although this was not significant after adjusting for confounders (AOR = 0.72, 95{\%}CI [0.38, 1.40]). The odds for early PTB (\32 weeks) were decreased in obese compared with normal weight African American women (OR = 0.23, 95{\%}CI [0.08, 0.70]), whereas they were increased in obese compared with normal weight Caucasian women (OR = 2.30, 95{\%}CI [1.32, 4.00]). Conclusion The risk for PTB in women with different prepregnancy BMI categories differs according to ethnicity.",
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AU - Torloni, Maria Regina

AU - Fortunato, Stephen J.

AU - Betrán, Ana Pilar

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AU - Brou, Lina

AU - Drobek, Cayce Owens

AU - Merialdi, Mario

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N2 - Purpose To investigate differences in pre-pregnancy BMI status in patients with spontaneous preterm birth (PTB) compared with term birth and assess the role of ethnicity as a risk modifier in BMI-associated PTB. Methods A case-control study involving self-reported African American and Caucasian women delivering singletons in Nashville, TN, USA, 2003-2009. Maternal prepregnancy BMI was recorded in 447 PTB-cases (African American = 145, Caucasian = 302) and 1315 term-birth controls (African American = 522; Caucasian = 793). Crude and adjusted odds ratio (OR and AOR) for PTB were calculated using normal BMI (18.5-24.9 kg/m2) as reference. Age, education, marital status, income, smoking, parity, previous PTB and pregnancy weight gain were included as covariates in logistic regression. Results No significant differences were noted in the OR for PTB among different BMI categories when women of different ethnicity were combined. Odds of PTB were greater in obese than in normal weight Caucasian women, even after adjusting for confounders (AOR = 1.84, 95%CI [1.15, 2.95]). Obese African American women had a decreased crude OR for PTB, although this was not significant after adjusting for confounders (AOR = 0.72, 95%CI [0.38, 1.40]). The odds for early PTB (\32 weeks) were decreased in obese compared with normal weight African American women (OR = 0.23, 95%CI [0.08, 0.70]), whereas they were increased in obese compared with normal weight Caucasian women (OR = 2.30, 95%CI [1.32, 4.00]). Conclusion The risk for PTB in women with different prepregnancy BMI categories differs according to ethnicity.

AB - Purpose To investigate differences in pre-pregnancy BMI status in patients with spontaneous preterm birth (PTB) compared with term birth and assess the role of ethnicity as a risk modifier in BMI-associated PTB. Methods A case-control study involving self-reported African American and Caucasian women delivering singletons in Nashville, TN, USA, 2003-2009. Maternal prepregnancy BMI was recorded in 447 PTB-cases (African American = 145, Caucasian = 302) and 1315 term-birth controls (African American = 522; Caucasian = 793). Crude and adjusted odds ratio (OR and AOR) for PTB were calculated using normal BMI (18.5-24.9 kg/m2) as reference. Age, education, marital status, income, smoking, parity, previous PTB and pregnancy weight gain were included as covariates in logistic regression. Results No significant differences were noted in the OR for PTB among different BMI categories when women of different ethnicity were combined. Odds of PTB were greater in obese than in normal weight Caucasian women, even after adjusting for confounders (AOR = 1.84, 95%CI [1.15, 2.95]). Obese African American women had a decreased crude OR for PTB, although this was not significant after adjusting for confounders (AOR = 0.72, 95%CI [0.38, 1.40]). The odds for early PTB (\32 weeks) were decreased in obese compared with normal weight African American women (OR = 0.23, 95%CI [0.08, 0.70]), whereas they were increased in obese compared with normal weight Caucasian women (OR = 2.30, 95%CI [1.32, 4.00]). Conclusion The risk for PTB in women with different prepregnancy BMI categories differs according to ethnicity.

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KW - Body mass index

KW - Ethnic groups

KW - European continental ancestry group

KW - Nutrition

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