Etiology of the pulmonary pathophysiology associated with inhalation injury

David Herndon, L. D. Traber, H. Linares, J. D. Flynn, G. Niehaus, George Kramer, D. L. Traber

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

This study describes an experimental model of smoke inhalation injury in sheep in which the same pathophysiologic alterations occur as with clinical inhalation injury in man. Diffuse pulmonary mucosal sloughing with atelectasis and emphysema with concommitant development of pulmonary edema results in a decrease in arterial oxygen and progressive pulmonary deterioration which results in a substantial mortality. Increased pulmonary edema fluid is shown to be caused by an increased microvascular permeability to protein with pulmonary lymph and tracheobronchial fluid, a filtrate of plasma. Concommitant with this increase in microvascular permeability is an influx of neutrophils, release of proteolytic enzymes and an identified presence of the metabolite of the prostanoid thromboxane A2 which are postulated as contributors to the progressive pulmonary dysfunction post inhalation injury.

Original languageEnglish (US)
Pages (from-to)43-59
Number of pages17
JournalResuscitation
Volume14
Issue number1-2
DOIs
StatePublished - 1986

Fingerprint

Inhalation
Lung
Wounds and Injuries
Capillary Permeability
Pulmonary Edema
Smoke Inhalation Injury
Thromboxane A2
Pulmonary Atelectasis
Emphysema
Lymph
Prostaglandins
Sheep
Neutrophils
Peptide Hydrolases
Theoretical Models
Oxygen
Mortality
Proteins

Keywords

  • Burn
  • Inhalation injury
  • Lung
  • Lung lymph
  • Pulmonary
  • Sheep
  • Smoke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nursing(all)

Cite this

Herndon, D., Traber, L. D., Linares, H., Flynn, J. D., Niehaus, G., Kramer, G., & Traber, D. L. (1986). Etiology of the pulmonary pathophysiology associated with inhalation injury. Resuscitation, 14(1-2), 43-59. https://doi.org/10.1016/0300-9572(86)90006-7

Etiology of the pulmonary pathophysiology associated with inhalation injury. / Herndon, David; Traber, L. D.; Linares, H.; Flynn, J. D.; Niehaus, G.; Kramer, George; Traber, D. L.

In: Resuscitation, Vol. 14, No. 1-2, 1986, p. 43-59.

Research output: Contribution to journalArticle

Herndon, D, Traber, LD, Linares, H, Flynn, JD, Niehaus, G, Kramer, G & Traber, DL 1986, 'Etiology of the pulmonary pathophysiology associated with inhalation injury', Resuscitation, vol. 14, no. 1-2, pp. 43-59. https://doi.org/10.1016/0300-9572(86)90006-7
Herndon, David ; Traber, L. D. ; Linares, H. ; Flynn, J. D. ; Niehaus, G. ; Kramer, George ; Traber, D. L. / Etiology of the pulmonary pathophysiology associated with inhalation injury. In: Resuscitation. 1986 ; Vol. 14, No. 1-2. pp. 43-59.
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