European contribution to the study of ROS

A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Ademowo, Catarina B. Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes & 131 others Mutay Aslan, Markus M. Bachschmid, Rui M. Barbosa, Vsevolod Belousov, Carsten Berndt, David Bernlohr, Esther Bertrán, Alberto Bindoli, Serge P. Bottari, Paula M. Brito, Guia Carrara, Ana I. Casas, Afroditi Chatzi, Niki Chondrogianni, Marcus Conrad, Marcus S. Cooke, João G. Costa, Antonio Cuadrado, Pham My-Chan Dang, Barbara De Smet, Bilge Debelec-Butuner, Irundika H.K. Dias, Joe Dan Dunn, Amanda J. Edson, Mariam El Assar, Jamel El-Benna, Péter Ferdinandy, Ana S. Fernandes, Kari E. Fladmark, Ulrich Förstermann, Rashid Giniatullin, Zoltán Giricz, Anikó Görbe, Helen Griffiths, Vaclav Hampl, Alina Hanf, Jan Herget, Pablo Hernansanz-Agustín, Melanie Hillion, Jingjing Huang, Serap Ilikay, Pidder Jansen-Dürr, Vincent Jaquet, Jaap A. Joles, Balaraman Kalyanaraman, Danylo Kaminskyy, Mahsa Karbaschi, Marina Kleanthous, Lars Oliver Klotz, Bato Korac, Kemal Sami Korkmaz, Rafal Koziel, Damir Kračun, Karl Heinz Krause, Vladimír Křen, Thomas Krieg, João Laranjinha, Antigone Lazou, Huige Li, Antonio Martínez-Ruiz, Reiko Matsui, Gethin J. McBean, Stuart P. Meredith, Joris Messens, Verónica Miguel, Yuliya Mikhed, Irina Milisav, Lidija Milković, Antonio Miranda-Vizuete, Miloš Mojović, María Monsalve, Pierre Alexis Mouthuy, John Mulvey, Thomas Münzel, Vladimir Muzykantov, Isabel T.N. Nguyen, Matthias Oelze, Nuno G. Oliveira, Carlos M. Palmeira, Nikoletta Papaevgeniou, Aleksandra Pavićević, Brandán Pedre, Fabienne Peyrot, Marios Phylactides, Gratiela G. Pircalabioru, Andrew R. Pitt, Henrik E. Poulsen, Ignacio Prieto, Maria Pia Rigobello, Natalia Robledinos-Antón, Leocadio Rodríguez-Mañas, Anabela P. Rolo, Francis Rousset, Tatjana Ruskovska, Nuno Saraiva, Shlomo Sasson, Katrin Schröder, Khrystyna Semen, Tamara Seredenina, Anastasia Shakirzyanova, Geoffrey L. Smith, Thierry Soldati, Bebiana C. Sousa, Corinne M. Spickett, Ana Stancic, Marie José Stasia, Holger Steinbrenner, Višnja Stepanić, Sebastian Steven, Kostas Tokatlidis, Erkan Tuncay, Belma Turan, Fulvio Ursini, Jan Vacek, Olga Vajnerova, Kateřina Valentová, Frank Van Breusegem, Lokman Varisli, Elizabeth A. Veal, A. Suha Yalçın, Olha Yelisyeyeva, Neven Žarković, Martina Zatloukalová, Jacek Zielonka, Rhian M. Touyz, Andreas Papapetropoulos, Tilman Grune, Santiago Lamas, Harald H.H.W. Schmidt, Fabio Di Lisa, Andreas Daiber

Research output: Contribution to journalReview article

74 Citations (Scopus)

Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

Original languageEnglish (US)
Pages (from-to)94-162
Number of pages69
JournalRedox Biology
Volume13
DOIs
StatePublished - Oct 1 2017
Externally publishedYes

Fingerprint

Reactive Nitrogen Species
Oxidation-Reduction
Oxidative stress
Technology
Reactive Oxygen Species
Oxidative Stress
Medicine
Antioxidants
Research
Metabolism
Disease Progression
Therapeutics
Research Personnel

Keywords

  • Antioxidants
  • Oxidative stress
  • Reactive nitrogen species
  • Reactive oxygen species
  • Redox signaling
  • Redox therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

Cite this

European contribution to the study of ROS : A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). / Egea, Javier; Fabregat, Isabel; Frapart, Yves M.; Ghezzi, Pietro; Görlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; Knaus, Ulla G.; Lopez, Manuela G.; Olaso-Gonzalez, Gloria; Petry, Andreas; Schulz, Rainer; Vina, Jose; Winyard, Paul; Abbas, Kahina; Ademowo, Opeyemi S.; Afonso, Catarina B.; Andreadou, Ioanna; Antelmann, Haike; Antunes, Fernando; Aslan, Mutay; Bachschmid, Markus M.; Barbosa, Rui M.; Belousov, Vsevolod; Berndt, Carsten; Bernlohr, David; Bertrán, Esther; Bindoli, Alberto; Bottari, Serge P.; Brito, Paula M.; Carrara, Guia; Casas, Ana I.; Chatzi, Afroditi; Chondrogianni, Niki; Conrad, Marcus; Cooke, Marcus S.; Costa, João G.; Cuadrado, Antonio; My-Chan Dang, Pham; De Smet, Barbara; Debelec-Butuner, Bilge; Dias, Irundika H.K.; Dunn, Joe Dan; Edson, Amanda J.; El Assar, Mariam; El-Benna, Jamel; Ferdinandy, Péter; Fernandes, Ana S.; Fladmark, Kari E.; Förstermann, Ulrich; Giniatullin, Rashid; Giricz, Zoltán; Görbe, Anikó; Griffiths, Helen; Hampl, Vaclav; Hanf, Alina; Herget, Jan; Hernansanz-Agustín, Pablo; Hillion, Melanie; Huang, Jingjing; Ilikay, Serap; Jansen-Dürr, Pidder; Jaquet, Vincent; Joles, Jaap A.; Kalyanaraman, Balaraman; Kaminskyy, Danylo; Karbaschi, Mahsa; Kleanthous, Marina; Klotz, Lars Oliver; Korac, Bato; Korkmaz, Kemal Sami; Koziel, Rafal; Kračun, Damir; Krause, Karl Heinz; Křen, Vladimír; Krieg, Thomas; Laranjinha, João; Lazou, Antigone; Li, Huige; Martínez-Ruiz, Antonio; Matsui, Reiko; McBean, Gethin J.; Meredith, Stuart P.; Messens, Joris; Miguel, Verónica; Mikhed, Yuliya; Milisav, Irina; Milković, Lidija; Miranda-Vizuete, Antonio; Mojović, Miloš; Monsalve, María; Mouthuy, Pierre Alexis; Mulvey, John; Münzel, Thomas; Muzykantov, Vladimir; Nguyen, Isabel T.N.; Oelze, Matthias; Oliveira, Nuno G.; Palmeira, Carlos M.; Papaevgeniou, Nikoletta; Pavićević, Aleksandra; Pedre, Brandán; Peyrot, Fabienne; Phylactides, Marios; Pircalabioru, Gratiela G.; Pitt, Andrew R.; Poulsen, Henrik E.; Prieto, Ignacio; Rigobello, Maria Pia; Robledinos-Antón, Natalia; Rodríguez-Mañas, Leocadio; Rolo, Anabela P.; Rousset, Francis; Ruskovska, Tatjana; Saraiva, Nuno; Sasson, Shlomo; Schröder, Katrin; Semen, Khrystyna; Seredenina, Tamara; Shakirzyanova, Anastasia; Smith, Geoffrey L.; Soldati, Thierry; Sousa, Bebiana C.; Spickett, Corinne M.; Stancic, Ana; Stasia, Marie José; Steinbrenner, Holger; Stepanić, Višnja; Steven, Sebastian; Tokatlidis, Kostas; Tuncay, Erkan; Turan, Belma; Ursini, Fulvio; Vacek, Jan; Vajnerova, Olga; Valentová, Kateřina; Van Breusegem, Frank; Varisli, Lokman; Veal, Elizabeth A.; Yalçın, A. Suha; Yelisyeyeva, Olha; Žarković, Neven; Zatloukalová, Martina; Zielonka, Jacek; Touyz, Rhian M.; Papapetropoulos, Andreas; Grune, Tilman; Lamas, Santiago; Schmidt, Harald H.H.W.; Di Lisa, Fabio; Daiber, Andreas.

In: Redox Biology, Vol. 13, 01.10.2017, p. 94-162.

Research output: Contribution to journalReview article

Egea, J, Fabregat, I, Frapart, YM, Ghezzi, P, Görlach, A, Kietzmann, T, Kubaichuk, K, Knaus, UG, Lopez, MG, Olaso-Gonzalez, G, Petry, A, Schulz, R, Vina, J, Winyard, P, Abbas, K, Ademowo, OS, Afonso, CB, Andreadou, I, Antelmann, H, Antunes, F, Aslan, M, Bachschmid, MM, Barbosa, RM, Belousov, V, Berndt, C, Bernlohr, D, Bertrán, E, Bindoli, A, Bottari, SP, Brito, PM, Carrara, G, Casas, AI, Chatzi, A, Chondrogianni, N, Conrad, M, Cooke, MS, Costa, JG, Cuadrado, A, My-Chan Dang, P, De Smet, B, Debelec-Butuner, B, Dias, IHK, Dunn, JD, Edson, AJ, El Assar, M, El-Benna, J, Ferdinandy, P, Fernandes, AS, Fladmark, KE, Förstermann, U, Giniatullin, R, Giricz, Z, Görbe, A, Griffiths, H, Hampl, V, Hanf, A, Herget, J, Hernansanz-Agustín, P, Hillion, M, Huang, J, Ilikay, S, Jansen-Dürr, P, Jaquet, V, Joles, JA, Kalyanaraman, B, Kaminskyy, D, Karbaschi, M, Kleanthous, M, Klotz, LO, Korac, B, Korkmaz, KS, Koziel, R, Kračun, D, Krause, KH, Křen, V, Krieg, T, Laranjinha, J, Lazou, A, Li, H, Martínez-Ruiz, A, Matsui, R, McBean, GJ, Meredith, SP, Messens, J, Miguel, V, Mikhed, Y, Milisav, I, Milković, L, Miranda-Vizuete, A, Mojović, M, Monsalve, M, Mouthuy, PA, Mulvey, J, Münzel, T, Muzykantov, V, Nguyen, ITN, Oelze, M, Oliveira, NG, Palmeira, CM, Papaevgeniou, N, Pavićević, A, Pedre, B, Peyrot, F, Phylactides, M, Pircalabioru, GG, Pitt, AR, Poulsen, HE, Prieto, I, Rigobello, MP, Robledinos-Antón, N, Rodríguez-Mañas, L, Rolo, AP, Rousset, F, Ruskovska, T, Saraiva, N, Sasson, S, Schröder, K, Semen, K, Seredenina, T, Shakirzyanova, A, Smith, GL, Soldati, T, Sousa, BC, Spickett, CM, Stancic, A, Stasia, MJ, Steinbrenner, H, Stepanić, V, Steven, S, Tokatlidis, K, Tuncay, E, Turan, B, Ursini, F, Vacek, J, Vajnerova, O, Valentová, K, Van Breusegem, F, Varisli, L, Veal, EA, Yalçın, AS, Yelisyeyeva, O, Žarković, N, Zatloukalová, M, Zielonka, J, Touyz, RM, Papapetropoulos, A, Grune, T, Lamas, S, Schmidt, HHHW, Di Lisa, F & Daiber, A 2017, 'European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)', Redox Biology, vol. 13, pp. 94-162. https://doi.org/10.1016/j.redox.2017.05.007
Egea, Javier ; Fabregat, Isabel ; Frapart, Yves M. ; Ghezzi, Pietro ; Görlach, Agnes ; Kietzmann, Thomas ; Kubaichuk, Kateryna ; Knaus, Ulla G. ; Lopez, Manuela G. ; Olaso-Gonzalez, Gloria ; Petry, Andreas ; Schulz, Rainer ; Vina, Jose ; Winyard, Paul ; Abbas, Kahina ; Ademowo, Opeyemi S. ; Afonso, Catarina B. ; Andreadou, Ioanna ; Antelmann, Haike ; Antunes, Fernando ; Aslan, Mutay ; Bachschmid, Markus M. ; Barbosa, Rui M. ; Belousov, Vsevolod ; Berndt, Carsten ; Bernlohr, David ; Bertrán, Esther ; Bindoli, Alberto ; Bottari, Serge P. ; Brito, Paula M. ; Carrara, Guia ; Casas, Ana I. ; Chatzi, Afroditi ; Chondrogianni, Niki ; Conrad, Marcus ; Cooke, Marcus S. ; Costa, João G. ; Cuadrado, Antonio ; My-Chan Dang, Pham ; De Smet, Barbara ; Debelec-Butuner, Bilge ; Dias, Irundika H.K. ; Dunn, Joe Dan ; Edson, Amanda J. ; El Assar, Mariam ; El-Benna, Jamel ; Ferdinandy, Péter ; Fernandes, Ana S. ; Fladmark, Kari E. ; Förstermann, Ulrich ; Giniatullin, Rashid ; Giricz, Zoltán ; Görbe, Anikó ; Griffiths, Helen ; Hampl, Vaclav ; Hanf, Alina ; Herget, Jan ; Hernansanz-Agustín, Pablo ; Hillion, Melanie ; Huang, Jingjing ; Ilikay, Serap ; Jansen-Dürr, Pidder ; Jaquet, Vincent ; Joles, Jaap A. ; Kalyanaraman, Balaraman ; Kaminskyy, Danylo ; Karbaschi, Mahsa ; Kleanthous, Marina ; Klotz, Lars Oliver ; Korac, Bato ; Korkmaz, Kemal Sami ; Koziel, Rafal ; Kračun, Damir ; Krause, Karl Heinz ; Křen, Vladimír ; Krieg, Thomas ; Laranjinha, João ; Lazou, Antigone ; Li, Huige ; Martínez-Ruiz, Antonio ; Matsui, Reiko ; McBean, Gethin J. ; Meredith, Stuart P. ; Messens, Joris ; Miguel, Verónica ; Mikhed, Yuliya ; Milisav, Irina ; Milković, Lidija ; Miranda-Vizuete, Antonio ; Mojović, Miloš ; Monsalve, María ; Mouthuy, Pierre Alexis ; Mulvey, John ; Münzel, Thomas ; Muzykantov, Vladimir ; Nguyen, Isabel T.N. ; Oelze, Matthias ; Oliveira, Nuno G. ; Palmeira, Carlos M. ; Papaevgeniou, Nikoletta ; Pavićević, Aleksandra ; Pedre, Brandán ; Peyrot, Fabienne ; Phylactides, Marios ; Pircalabioru, Gratiela G. ; Pitt, Andrew R. ; Poulsen, Henrik E. ; Prieto, Ignacio ; Rigobello, Maria Pia ; Robledinos-Antón, Natalia ; Rodríguez-Mañas, Leocadio ; Rolo, Anabela P. ; Rousset, Francis ; Ruskovska, Tatjana ; Saraiva, Nuno ; Sasson, Shlomo ; Schröder, Katrin ; Semen, Khrystyna ; Seredenina, Tamara ; Shakirzyanova, Anastasia ; Smith, Geoffrey L. ; Soldati, Thierry ; Sousa, Bebiana C. ; Spickett, Corinne M. ; Stancic, Ana ; Stasia, Marie José ; Steinbrenner, Holger ; Stepanić, Višnja ; Steven, Sebastian ; Tokatlidis, Kostas ; Tuncay, Erkan ; Turan, Belma ; Ursini, Fulvio ; Vacek, Jan ; Vajnerova, Olga ; Valentová, Kateřina ; Van Breusegem, Frank ; Varisli, Lokman ; Veal, Elizabeth A. ; Yalçın, A. Suha ; Yelisyeyeva, Olha ; Žarković, Neven ; Zatloukalová, Martina ; Zielonka, Jacek ; Touyz, Rhian M. ; Papapetropoulos, Andreas ; Grune, Tilman ; Lamas, Santiago ; Schmidt, Harald H.H.W. ; Di Lisa, Fabio ; Daiber, Andreas. / European contribution to the study of ROS : A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). In: Redox Biology. 2017 ; Vol. 13. pp. 94-162.
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title = "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)",
abstract = "The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.",
keywords = "Antioxidants, Oxidative stress, Reactive nitrogen species, Reactive oxygen species, Redox signaling, Redox therapeutics",
author = "Javier Egea and Isabel Fabregat and Frapart, {Yves M.} and Pietro Ghezzi and Agnes G{\"o}rlach and Thomas Kietzmann and Kateryna Kubaichuk and Knaus, {Ulla G.} and Lopez, {Manuela G.} and Gloria Olaso-Gonzalez and Andreas Petry and Rainer Schulz and Jose Vina and Paul Winyard and Kahina Abbas and Ademowo, {Opeyemi S.} and Afonso, {Catarina B.} and Ioanna Andreadou and Haike Antelmann and Fernando Antunes and Mutay Aslan and Bachschmid, {Markus M.} and Barbosa, {Rui M.} and Vsevolod Belousov and Carsten Berndt and David Bernlohr and Esther Bertr{\'a}n and Alberto Bindoli and Bottari, {Serge P.} and Brito, {Paula M.} and Guia Carrara and Casas, {Ana I.} and Afroditi Chatzi and Niki Chondrogianni and Marcus Conrad and Cooke, {Marcus S.} and Costa, {Jo{\~a}o G.} and Antonio Cuadrado and {My-Chan Dang}, Pham and {De Smet}, Barbara and Bilge Debelec-Butuner and Dias, {Irundika H.K.} and Dunn, {Joe Dan} and Edson, {Amanda J.} and {El Assar}, Mariam and Jamel El-Benna and P{\'e}ter Ferdinandy and Fernandes, {Ana S.} and Fladmark, {Kari E.} and Ulrich F{\"o}rstermann and Rashid Giniatullin and Zolt{\'a}n Giricz and Anik{\'o} G{\"o}rbe and Helen Griffiths and Vaclav Hampl and Alina Hanf and Jan Herget and Pablo Hernansanz-Agust{\'i}n and Melanie Hillion and Jingjing Huang and Serap Ilikay and Pidder Jansen-D{\"u}rr and Vincent Jaquet and Joles, {Jaap A.} and Balaraman Kalyanaraman and Danylo Kaminskyy and Mahsa Karbaschi and Marina Kleanthous and Klotz, {Lars Oliver} and Bato Korac and Korkmaz, {Kemal Sami} and Rafal Koziel and Damir Kračun and Krause, {Karl Heinz} and Vladim{\'i}r Křen and Thomas Krieg and Jo{\~a}o Laranjinha and Antigone Lazou and Huige Li and Antonio Mart{\'i}nez-Ruiz and Reiko Matsui and McBean, {Gethin J.} and Meredith, {Stuart P.} and Joris Messens and Ver{\'o}nica Miguel and Yuliya Mikhed and Irina Milisav and Lidija Milković and Antonio Miranda-Vizuete and Miloš Mojović and Mar{\'i}a Monsalve and Mouthuy, {Pierre Alexis} and John Mulvey and Thomas M{\"u}nzel and Vladimir Muzykantov and Nguyen, {Isabel T.N.} and Matthias Oelze and Oliveira, {Nuno G.} and Palmeira, {Carlos M.} and Nikoletta Papaevgeniou and Aleksandra Pavićević and Brand{\'a}n Pedre and Fabienne Peyrot and Marios Phylactides and Pircalabioru, {Gratiela G.} and Pitt, {Andrew R.} and Poulsen, {Henrik E.} and Ignacio Prieto and Rigobello, {Maria Pia} and Natalia Robledinos-Ant{\'o}n and Leocadio Rodr{\'i}guez-Ma{\~n}as and Rolo, {Anabela P.} and Francis Rousset and Tatjana Ruskovska and Nuno Saraiva and Shlomo Sasson and Katrin Schr{\"o}der and Khrystyna Semen and Tamara Seredenina and Anastasia Shakirzyanova and Smith, {Geoffrey L.} and Thierry Soldati and Sousa, {Bebiana C.} and Spickett, {Corinne M.} and Ana Stancic and Stasia, {Marie Jos{\'e}} and Holger Steinbrenner and Višnja Stepanić and Sebastian Steven and Kostas Tokatlidis and Erkan Tuncay and Belma Turan and Fulvio Ursini and Jan Vacek and Olga Vajnerova and Kateřina Valentov{\'a} and {Van Breusegem}, Frank and Lokman Varisli and Veal, {Elizabeth A.} and Yal{\cc}ın, {A. Suha} and Olha Yelisyeyeva and Neven Žarković and Martina Zatloukalov{\'a} and Jacek Zielonka and Touyz, {Rhian M.} and Andreas Papapetropoulos and Tilman Grune and Santiago Lamas and Schmidt, {Harald H.H.W.} and {Di Lisa}, Fabio and Andreas Daiber",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.redox.2017.05.007",
language = "English (US)",
volume = "13",
pages = "94--162",
journal = "Redox Biology",
issn = "2213-2317",
publisher = "Elsevier BV",

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TY - JOUR

T1 - European contribution to the study of ROS

T2 - A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

AU - Egea, Javier

AU - Fabregat, Isabel

AU - Frapart, Yves M.

AU - Ghezzi, Pietro

AU - Görlach, Agnes

AU - Kietzmann, Thomas

AU - Kubaichuk, Kateryna

AU - Knaus, Ulla G.

AU - Lopez, Manuela G.

AU - Olaso-Gonzalez, Gloria

AU - Petry, Andreas

AU - Schulz, Rainer

AU - Vina, Jose

AU - Winyard, Paul

AU - Abbas, Kahina

AU - Ademowo, Opeyemi S.

AU - Afonso, Catarina B.

AU - Andreadou, Ioanna

AU - Antelmann, Haike

AU - Antunes, Fernando

AU - Aslan, Mutay

AU - Bachschmid, Markus M.

AU - Barbosa, Rui M.

AU - Belousov, Vsevolod

AU - Berndt, Carsten

AU - Bernlohr, David

AU - Bertrán, Esther

AU - Bindoli, Alberto

AU - Bottari, Serge P.

AU - Brito, Paula M.

AU - Carrara, Guia

AU - Casas, Ana I.

AU - Chatzi, Afroditi

AU - Chondrogianni, Niki

AU - Conrad, Marcus

AU - Cooke, Marcus S.

AU - Costa, João G.

AU - Cuadrado, Antonio

AU - My-Chan Dang, Pham

AU - De Smet, Barbara

AU - Debelec-Butuner, Bilge

AU - Dias, Irundika H.K.

AU - Dunn, Joe Dan

AU - Edson, Amanda J.

AU - El Assar, Mariam

AU - El-Benna, Jamel

AU - Ferdinandy, Péter

AU - Fernandes, Ana S.

AU - Fladmark, Kari E.

AU - Förstermann, Ulrich

AU - Giniatullin, Rashid

AU - Giricz, Zoltán

AU - Görbe, Anikó

AU - Griffiths, Helen

AU - Hampl, Vaclav

AU - Hanf, Alina

AU - Herget, Jan

AU - Hernansanz-Agustín, Pablo

AU - Hillion, Melanie

AU - Huang, Jingjing

AU - Ilikay, Serap

AU - Jansen-Dürr, Pidder

AU - Jaquet, Vincent

AU - Joles, Jaap A.

AU - Kalyanaraman, Balaraman

AU - Kaminskyy, Danylo

AU - Karbaschi, Mahsa

AU - Kleanthous, Marina

AU - Klotz, Lars Oliver

AU - Korac, Bato

AU - Korkmaz, Kemal Sami

AU - Koziel, Rafal

AU - Kračun, Damir

AU - Krause, Karl Heinz

AU - Křen, Vladimír

AU - Krieg, Thomas

AU - Laranjinha, João

AU - Lazou, Antigone

AU - Li, Huige

AU - Martínez-Ruiz, Antonio

AU - Matsui, Reiko

AU - McBean, Gethin J.

AU - Meredith, Stuart P.

AU - Messens, Joris

AU - Miguel, Verónica

AU - Mikhed, Yuliya

AU - Milisav, Irina

AU - Milković, Lidija

AU - Miranda-Vizuete, Antonio

AU - Mojović, Miloš

AU - Monsalve, María

AU - Mouthuy, Pierre Alexis

AU - Mulvey, John

AU - Münzel, Thomas

AU - Muzykantov, Vladimir

AU - Nguyen, Isabel T.N.

AU - Oelze, Matthias

AU - Oliveira, Nuno G.

AU - Palmeira, Carlos M.

AU - Papaevgeniou, Nikoletta

AU - Pavićević, Aleksandra

AU - Pedre, Brandán

AU - Peyrot, Fabienne

AU - Phylactides, Marios

AU - Pircalabioru, Gratiela G.

AU - Pitt, Andrew R.

AU - Poulsen, Henrik E.

AU - Prieto, Ignacio

AU - Rigobello, Maria Pia

AU - Robledinos-Antón, Natalia

AU - Rodríguez-Mañas, Leocadio

AU - Rolo, Anabela P.

AU - Rousset, Francis

AU - Ruskovska, Tatjana

AU - Saraiva, Nuno

AU - Sasson, Shlomo

AU - Schröder, Katrin

AU - Semen, Khrystyna

AU - Seredenina, Tamara

AU - Shakirzyanova, Anastasia

AU - Smith, Geoffrey L.

AU - Soldati, Thierry

AU - Sousa, Bebiana C.

AU - Spickett, Corinne M.

AU - Stancic, Ana

AU - Stasia, Marie José

AU - Steinbrenner, Holger

AU - Stepanić, Višnja

AU - Steven, Sebastian

AU - Tokatlidis, Kostas

AU - Tuncay, Erkan

AU - Turan, Belma

AU - Ursini, Fulvio

AU - Vacek, Jan

AU - Vajnerova, Olga

AU - Valentová, Kateřina

AU - Van Breusegem, Frank

AU - Varisli, Lokman

AU - Veal, Elizabeth A.

AU - Yalçın, A. Suha

AU - Yelisyeyeva, Olha

AU - Žarković, Neven

AU - Zatloukalová, Martina

AU - Zielonka, Jacek

AU - Touyz, Rhian M.

AU - Papapetropoulos, Andreas

AU - Grune, Tilman

AU - Lamas, Santiago

AU - Schmidt, Harald H.H.W.

AU - Di Lisa, Fabio

AU - Daiber, Andreas

PY - 2017/10/1

Y1 - 2017/10/1

N2 - The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

AB - The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

KW - Antioxidants

KW - Oxidative stress

KW - Reactive nitrogen species

KW - Reactive oxygen species

KW - Redox signaling

KW - Redox therapeutics

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U2 - 10.1016/j.redox.2017.05.007

DO - 10.1016/j.redox.2017.05.007

M3 - Review article

VL - 13

SP - 94

EP - 162

JO - Redox Biology

JF - Redox Biology

SN - 2213-2317

ER -