Evaluating quality of life of extracorporeal membrane oxygenation survivors using the pediatric quality of life inventory survey

Yangyang R. Yu, Jennifer L. Carpenter, Annalyn S. DeMello, Sundeep G. Keswani, Darrell L. Cass, Oluyinka O. Olutoye, Adam M. Vogel, James A. Thomas, Cole Burgman, Caraciolo J. Fernandes, Timothy C. Lee

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Purpose: This study assesses the impact of extracorporeal membrane oxygenation (ECMO) associated morbidities on long-term quality of life (QOL) outcomes. Methods: A single center, retrospective review of neonatal and pediatric non-cardiac ECMO survivors from 1/2005–7/2016 was performed. The 2012 Pediatric Quality of Life Inventory™ (PedsQL™) survey was administered. Clinical outcomes and QOL scores between groups were compared. Results: Of 74 patients eligible, 64% (35 NICU, 12 PICU) completed the survey. Mean time since ECMO was 5.5 ± 3 years. ECMO duration for venoarterial (VA) and venovenous (VV) were similar (median 9 vs. 7.5 days, p = 0.09). VA ECMO had higher overall complication rate (64% vs. 36%, p = 0.06) and higher neurologic complication rate (52% vs. 9%, p = 0.002). ECMO mode and ICU type did not impact QOL. However, patients with neurologic complications (n = 15) showed a trend towards lower overall QOL (63/100 ± 20 vs. 74/100 ± 18, p = 0.06) compared to patients without neurologic complications. A subset analysis of patients with ischemic or hemorrhagic intracranial injuries (n = 13) had significantly lower overall QOL (59/100 ± 19 vs. 75/100 ± 18, p = 0.01) compared to patients without intracranial injuries. Conclusion: Neurologic complication following ECMO is common, associated with VA mode, and negatively impacts long-term QOL. Given these associations, when clinically feasible, VV ECMO may be considered as first line ECMO therapy. Type of study: Retrospective review.

Original languageEnglish (US)
Pages (from-to)1060-1064
Number of pages5
JournalJournal of Pediatric Surgery
Issue number5
StatePublished - May 2018
Externally publishedYes


  • Extracorporeal membrane oxygenation
  • Intracranial injury
  • Pediatric
  • Quality of life
  • Venoarterial
  • Venovenous

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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