Evaluation of 5-hydroxytryptophan administration as a test of pineal function in humans

A. Cavallo, G. E. Richards, Walter Meyer, R. D. Waldrop

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We tested the hypothesis that acute 5-hydroxytryptophan (5-HTP) administration would cause an increase in concentrations of plasma melatonin to levels observed during the spontaneous nocturnal melatonin surge. We administered 5-HTP orally (5-12 mg/kg) to 10 healthy children and 5 healthy adults, and measured melatonin concentrations in plasma samples obtained every 30 min for 3-6 h. There was no appreciable increase in melatonin after 5-HTP stimulation, even though a melatonin increase has been reported in sheep treated with 5-HTP.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
JournalHormone Research
Volume27
Issue number2
StatePublished - 1987

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5-Hydroxytryptophan
Melatonin
Sheep

ASJC Scopus subject areas

  • Endocrinology

Cite this

Cavallo, A., Richards, G. E., Meyer, W., & Waldrop, R. D. (1987). Evaluation of 5-hydroxytryptophan administration as a test of pineal function in humans. Hormone Research, 27(2), 69-73.

Evaluation of 5-hydroxytryptophan administration as a test of pineal function in humans. / Cavallo, A.; Richards, G. E.; Meyer, Walter; Waldrop, R. D.

In: Hormone Research, Vol. 27, No. 2, 1987, p. 69-73.

Research output: Contribution to journalArticle

Cavallo, A, Richards, GE, Meyer, W & Waldrop, RD 1987, 'Evaluation of 5-hydroxytryptophan administration as a test of pineal function in humans', Hormone Research, vol. 27, no. 2, pp. 69-73.
Cavallo, A. ; Richards, G. E. ; Meyer, Walter ; Waldrop, R. D. / Evaluation of 5-hydroxytryptophan administration as a test of pineal function in humans. In: Hormone Research. 1987 ; Vol. 27, No. 2. pp. 69-73.
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