Evaluation of a long-chain polyunsaturated fatty acid supplemented formula on growth, tolerance, and plasma lipids in preterm infants up to 48 weeks postconceptional age

Jon Vanderhoof, Steven Gross, Thomas Hegyi, Thomas Clandinin, Peter Porcelli, Joseph DeCristofaro, Torunn Rhodes, Reginald Tsang, Karen Shattuck, Richard Cowett, David Adamkin, Cecilia McCarton, William Heird, Brenda Hook-Morris, Gilberto Pereira, Gary Chan, John Van Aerde, Frances Boyle, Kathryn Pramuk, Arthur Euler & 1 others Eric L. Lien

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: The last trimester of pregnancy is a period of rapid accretion of long-chain polyunsaturated fatty acids, both in the central nervous system and the body as a whole. Human milk contains these fatty acids, whereas some preterm infant formulas do not. Infants fed formulas without these fatty acids have lower plasma and erythrocyte concentrations than infants fed human milk. Preclinical and clinical studies have demonstrated that single-cell sources (algal and fungal) of long-chain polyunsaturated fatty acids are bioavailable. A balanced addition of fatty acids from these oils to preterm formula results in blood fatty acid concentrations in low birth weight infants comparable to those of infants fed human milk. Methods: In the present study the growth, acceptance (overall incidence of discontinuation, reasons for discontinuation, overall incidence and type of individual adverse events), and plasma fatty acid concentrations were compared in three groups of infants fed a long-chain polyunsaturated fatty acid-supplemented preterm infant formula, an unsupplemented control formula, or human milk. The study was prospective, double-blind (formula groups only), and randomized (formula groups only). Two hundred eighty-eight infants were enrolled (supplemented formula group, n = 77; control formula group, n = 78; human milk group, n = 133). Results: Anthropometric measurements at enrollment, at first day of full oral feeding, and at both 40 and 48 weeks postconceptional age did not differ between the formula groups, whereas the human milk-fed group initially grew at a lower rate. The incidence of severe adverse events was rare and not significantly different between formula groups. The groups fed either human milk or supplemented formula had long-chain polyunsaturated fatty acid concentrations higher than those in the control formula group. Conclusions: The results of this study demonstrate the safety and efficacy of a preterm formula supplemented with longchain polyunsaturated fatty acids from single-cell oils. (C) 1999 Lippincott Williams and Wilkins, Inc.

Original languageEnglish (US)
Pages (from-to)318-326
Number of pages9
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume29
Issue number3
DOIs
StatePublished - Sep 1999

Fingerprint

long chain polyunsaturated fatty acids
Human Milk
breast milk
Unsaturated Fatty Acids
Premature Infants
blood lipids
Lipids
Fatty Acids
Infant Formula
Growth
fatty acids
infant formulas
incidence
Incidence
Oils
oils
Control Groups
low birth weight
Third Pregnancy Trimester
Low Birth Weight Infant

Keywords

  • Arachidonic acid
  • Docosahexaenoic acid
  • Long-chain polyunsaturated fatty acids
  • Low birth weight

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Evaluation of a long-chain polyunsaturated fatty acid supplemented formula on growth, tolerance, and plasma lipids in preterm infants up to 48 weeks postconceptional age. / Vanderhoof, Jon; Gross, Steven; Hegyi, Thomas; Clandinin, Thomas; Porcelli, Peter; DeCristofaro, Joseph; Rhodes, Torunn; Tsang, Reginald; Shattuck, Karen; Cowett, Richard; Adamkin, David; McCarton, Cecilia; Heird, William; Hook-Morris, Brenda; Pereira, Gilberto; Chan, Gary; Van Aerde, John; Boyle, Frances; Pramuk, Kathryn; Euler, Arthur; Lien, Eric L.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 29, No. 3, 09.1999, p. 318-326.

Research output: Contribution to journalArticle

Vanderhoof, J, Gross, S, Hegyi, T, Clandinin, T, Porcelli, P, DeCristofaro, J, Rhodes, T, Tsang, R, Shattuck, K, Cowett, R, Adamkin, D, McCarton, C, Heird, W, Hook-Morris, B, Pereira, G, Chan, G, Van Aerde, J, Boyle, F, Pramuk, K, Euler, A & Lien, EL 1999, 'Evaluation of a long-chain polyunsaturated fatty acid supplemented formula on growth, tolerance, and plasma lipids in preterm infants up to 48 weeks postconceptional age', Journal of Pediatric Gastroenterology and Nutrition, vol. 29, no. 3, pp. 318-326. https://doi.org/10.1097/00005176-199909000-00015
Vanderhoof, Jon ; Gross, Steven ; Hegyi, Thomas ; Clandinin, Thomas ; Porcelli, Peter ; DeCristofaro, Joseph ; Rhodes, Torunn ; Tsang, Reginald ; Shattuck, Karen ; Cowett, Richard ; Adamkin, David ; McCarton, Cecilia ; Heird, William ; Hook-Morris, Brenda ; Pereira, Gilberto ; Chan, Gary ; Van Aerde, John ; Boyle, Frances ; Pramuk, Kathryn ; Euler, Arthur ; Lien, Eric L. / Evaluation of a long-chain polyunsaturated fatty acid supplemented formula on growth, tolerance, and plasma lipids in preterm infants up to 48 weeks postconceptional age. In: Journal of Pediatric Gastroenterology and Nutrition. 1999 ; Vol. 29, No. 3. pp. 318-326.
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AU - Vanderhoof, Jon

AU - Gross, Steven

AU - Hegyi, Thomas

AU - Clandinin, Thomas

AU - Porcelli, Peter

AU - DeCristofaro, Joseph

AU - Rhodes, Torunn

AU - Tsang, Reginald

AU - Shattuck, Karen

AU - Cowett, Richard

AU - Adamkin, David

AU - McCarton, Cecilia

AU - Heird, William

AU - Hook-Morris, Brenda

AU - Pereira, Gilberto

AU - Chan, Gary

AU - Van Aerde, John

AU - Boyle, Frances

AU - Pramuk, Kathryn

AU - Euler, Arthur

AU - Lien, Eric L.

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N2 - Background: The last trimester of pregnancy is a period of rapid accretion of long-chain polyunsaturated fatty acids, both in the central nervous system and the body as a whole. Human milk contains these fatty acids, whereas some preterm infant formulas do not. Infants fed formulas without these fatty acids have lower plasma and erythrocyte concentrations than infants fed human milk. Preclinical and clinical studies have demonstrated that single-cell sources (algal and fungal) of long-chain polyunsaturated fatty acids are bioavailable. A balanced addition of fatty acids from these oils to preterm formula results in blood fatty acid concentrations in low birth weight infants comparable to those of infants fed human milk. Methods: In the present study the growth, acceptance (overall incidence of discontinuation, reasons for discontinuation, overall incidence and type of individual adverse events), and plasma fatty acid concentrations were compared in three groups of infants fed a long-chain polyunsaturated fatty acid-supplemented preterm infant formula, an unsupplemented control formula, or human milk. The study was prospective, double-blind (formula groups only), and randomized (formula groups only). Two hundred eighty-eight infants were enrolled (supplemented formula group, n = 77; control formula group, n = 78; human milk group, n = 133). Results: Anthropometric measurements at enrollment, at first day of full oral feeding, and at both 40 and 48 weeks postconceptional age did not differ between the formula groups, whereas the human milk-fed group initially grew at a lower rate. The incidence of severe adverse events was rare and not significantly different between formula groups. The groups fed either human milk or supplemented formula had long-chain polyunsaturated fatty acid concentrations higher than those in the control formula group. Conclusions: The results of this study demonstrate the safety and efficacy of a preterm formula supplemented with longchain polyunsaturated fatty acids from single-cell oils. (C) 1999 Lippincott Williams and Wilkins, Inc.

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KW - Docosahexaenoic acid

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