Evaluation of an intraosseous infusion device for the resuscitation of hypovolemic shock

L. Halvorsen, B. K. Bay, P. R. Perron, R. A. Gunther, J. W. Holcroft, F. W. Blaisdell, George Kramer

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

An intraosseous infusion device designed for the prehospital administration of hypertonic saline-dextran solutions was evaluated by resuscitating hemorrhaged conscious sheep. Eight animals underwent 2 hours of hemorrhagic hypotension (50 mm Hg, bled volume = 43 ± 7 ml/kg). This was followed by the intraosseous infusion of 200 ml (4-5 ml/kg) of 7.5% NaCl-6% dextran 70 into the bone marrow of the sternum. Results were compared to seven control animals (bled volume = 31 ± 6 ml/kg) resuscitated through a central venous catheter. Despite the small volumes infused, mean arterial blood pressure and cardiac output were rapidly normalized in both groups by 10 minutes post resuscitation (p < 0.01). Plasma sodium concentration increased an average of 12 mEq/L and plasma volume was rapidly expanded regardless of route. The metabolic acidosis of hemorrhagic shock was rapidly corrected, pulmonary pressures remained normal, and hypoxemia did not occur after intraosseous resuscitation. The device provided safe and rapid vascular access via the sternal bone marrow space. The use of intraosseous infusion of hypertonic saline dextran solutions via the sternal bone marrow may allow prehospital rescuers to consistently incorporate fluid replacement therapy into 'scoop and run' policies by avoiding the time delays associated with failures in IV access.

Original languageEnglish (US)
Pages (from-to)652-659
Number of pages8
JournalJournal of Trauma
Volume30
Issue number6
StatePublished - 1990
Externally publishedYes

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Intraosseous Infusions
Resuscitation
Shock
Bone Marrow
Equipment and Supplies
Arterial Pressure
Sternum
Hemorrhagic Shock
Central Venous Catheters
Plasma Volume
Fluid Therapy
Acidosis
Dextrans
Cardiac Output
Hypotension
Blood Vessels
Sheep
Sodium
Pressure
Lung

ASJC Scopus subject areas

  • Surgery

Cite this

Halvorsen, L., Bay, B. K., Perron, P. R., Gunther, R. A., Holcroft, J. W., Blaisdell, F. W., & Kramer, G. (1990). Evaluation of an intraosseous infusion device for the resuscitation of hypovolemic shock. Journal of Trauma, 30(6), 652-659.

Evaluation of an intraosseous infusion device for the resuscitation of hypovolemic shock. / Halvorsen, L.; Bay, B. K.; Perron, P. R.; Gunther, R. A.; Holcroft, J. W.; Blaisdell, F. W.; Kramer, George.

In: Journal of Trauma, Vol. 30, No. 6, 1990, p. 652-659.

Research output: Contribution to journalArticle

Halvorsen, L, Bay, BK, Perron, PR, Gunther, RA, Holcroft, JW, Blaisdell, FW & Kramer, G 1990, 'Evaluation of an intraosseous infusion device for the resuscitation of hypovolemic shock', Journal of Trauma, vol. 30, no. 6, pp. 652-659.
Halvorsen L, Bay BK, Perron PR, Gunther RA, Holcroft JW, Blaisdell FW et al. Evaluation of an intraosseous infusion device for the resuscitation of hypovolemic shock. Journal of Trauma. 1990;30(6):652-659.
Halvorsen, L. ; Bay, B. K. ; Perron, P. R. ; Gunther, R. A. ; Holcroft, J. W. ; Blaisdell, F. W. ; Kramer, George. / Evaluation of an intraosseous infusion device for the resuscitation of hypovolemic shock. In: Journal of Trauma. 1990 ; Vol. 30, No. 6. pp. 652-659.
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