TY - JOUR
T1 - Evaluation of cardiovascular responses to silver nanoparticles (AgNPs) in spontaneously hypertensive rats
AU - Ramirez-Lee, Manuel Alejandro
AU - Aguirre-Bañuelos, Patricia
AU - Martinez-Cuevas, Pedro Pablo
AU - Espinosa-Tanguma, Ricardo
AU - Chi-Ahumada, Erika
AU - Martinez-Castañon, Gabriel Alejandro
AU - Gonzalez, Carmen
N1 - Funding Information:
This work was supported by Consejo Nacional de Ciencia y Tecnologia through the fellowship of Ramirez-Lee ( 318669 ) and the grants C15-FAI-04-33.33 ; C15-PIFI-06-02.02 and C16-PIFI-09-08.08 .
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/2
Y1 - 2018/2
N2 - Silver nanoparticles (AgNPs) are used in the medical, pharmaceutical and food industry. Adverse effects and toxicity induced by AgNPs upon cardiac function related to nitric oxide (NO) and oxidative stress (OS) are described. AgNPs-toxicity may be influenced by cardiovascular pathologies such as hypertension. However, the molecules involved under pathophysiological conditions are not well studied. The aim of this work was to evaluate perfusion pressure (PP) and left ventricle pressure (LVP) as physiological parameters of cardiovascular function in response to AgNPs, using isolated perfused hearts from spontaneously hypertensive rats (SHR), and identify the role of NO and OS. The results suggest that AgNPs reduced NO derived from endothelial/inducible NO-synthase and increased OS, leading to increased and sustained vasoconstriction and myocardial contractility. Additionally, the hypertension condition alters phenylephrine (Phe) and acetylcholine (ACh) classic effects. These data suggest that hypertension intensified AgNPs-cardiotoxicity. Nevertheless, the precise mechanism of action is still under elucidation.
AB - Silver nanoparticles (AgNPs) are used in the medical, pharmaceutical and food industry. Adverse effects and toxicity induced by AgNPs upon cardiac function related to nitric oxide (NO) and oxidative stress (OS) are described. AgNPs-toxicity may be influenced by cardiovascular pathologies such as hypertension. However, the molecules involved under pathophysiological conditions are not well studied. The aim of this work was to evaluate perfusion pressure (PP) and left ventricle pressure (LVP) as physiological parameters of cardiovascular function in response to AgNPs, using isolated perfused hearts from spontaneously hypertensive rats (SHR), and identify the role of NO and OS. The results suggest that AgNPs reduced NO derived from endothelial/inducible NO-synthase and increased OS, leading to increased and sustained vasoconstriction and myocardial contractility. Additionally, the hypertension condition alters phenylephrine (Phe) and acetylcholine (ACh) classic effects. These data suggest that hypertension intensified AgNPs-cardiotoxicity. Nevertheless, the precise mechanism of action is still under elucidation.
KW - Nitric oxide
KW - Oxidative stress
KW - Silver nanoparticles
KW - Spontaneously hypertensive rats
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U2 - 10.1016/j.nano.2017.11.013
DO - 10.1016/j.nano.2017.11.013
M3 - Article
C2 - 29175596
AN - SCOPUS:85037976989
SN - 1549-9634
VL - 14
SP - 385
EP - 395
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
IS - 2
ER -