Evaluation of Immune‐enhancing Effects of Ibuprofen in an Immunodeficiency Model

Joseph L. Jorizzo, Randall M. Goldblum, Jerry C. Daniels, Yukinobu Ichikawa, Marlyn P. Langford, Karis M. Fagan

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Abstract: Three children and one adult with chronic mucocutaneous candidosis with documented deficient cellular immunity to Candida antigen were evaluated as a model to study the specific cellular immune‐enhancing potential of the prostaglandin synthetase inhibitor ibuprofen. Oral ibuprofen failed to have any consistent effect during sequential 4‐week on and off cycles on the following parameters: delayed hypersensitivity skin testing; lymphocyte transformation to Candida antigen; T‐cell subsets as determined by monoclonal antibody techniques; production of human immune interferon in response to staphylococcal enterotoxin A (SEA). Two patients showed a trend toward enhanced lymphocyte transformation to PHA while taking ibuprofen. In two patients who were studied 8–10 weeks after discontinuation of oral ketoconazole therapy, clinical recurrence of CMC was not prevented by oral ibuproten therapy.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalInternational Journal of Dermatology
Issue number1
StatePublished - Jan 1985

ASJC Scopus subject areas

  • Dermatology


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