Evaluation of plasma inflammatory cytokine concentrations in racing sled dogs

Dirsko J.F. von Pfeil, Bethany P. Cummings, John P. Loftus, Corri B. Levine, Sabine Mann, Robert L. Downey, Caroline Griffitts, Joseph J. Wakshlag

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


In human athletes significant changes in cytokine concentrations secondary to exercise have been observed. This prospective study evaluated the effect of a multi-day stage sled dog race on plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). Samples from 20 dogs were harvested prior to and on days 2 and 8 of an 8-day race. Exercise resulted in significantly decreased TNF-α and IL-8 as well as increases of MCP-1, IL-6, and IL-10 concentrations (P-value between 0.01 and < 0.0001 for all parameters). The proportion of values for IL-2 that were below the detection limit increased from 40% on day 0 to 75% on day 2 and decreased on day 8 to 40% (P = 0.04). Racing sled dogs show cytokine-concentration changes that are different from those in humans.

Original languageEnglish (US)
Pages (from-to)1252-1256
Number of pages5
JournalCanadian Veterinary Journal
Issue number12
StatePublished - Dec 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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