Evaluation of plasma inflammatory cytokine concentrations in racing sled dogs

Dirsko J.F. von Pfeil; Bethany P. Cummings; John P. Loftus; Corri B. Levine; Sabine Mann; Robert L. Downey; Caroline Griffitts; Joseph J. Wakshlag

Evaluation of plasma inflammatory cytokine concentrations in racing sled dogs

Dirsko J.F. von Pfeil, Bethany P. Cummings, John P. Loftus, Corri B. Levine, Sabine Mann, Robert L. Downey, Caroline Griffitts, Joseph J. Wakshlag

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

In human athletes significant changes in cytokine concentrations secondary to exercise have been observed. This prospective study evaluated the effect of a multi-day stage sled dog race on plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). Samples from 20 dogs were harvested prior to and on days 2 and 8 of an 8-day race. Exercise resulted in significantly decreased TNF-α and IL-8 as well as increases of MCP-1, IL-6, and IL-10 concentrations (P-value between 0.01 and < 0.0001 for all parameters). The proportion of values for IL-2 that were below the detection limit increased from 40% on day 0 to 75% on day 2 and decreased on day 8 to 40% (P = 0.04). Racing sled dogs show cytokine-concentration changes that are different from those in humans.

Original language	English (US)
Pages (from-to)	1252-1256
Number of pages	5
Journal	Canadian Veterinary Journal
Volume	56
Issue number	12
State	Published - Dec 1 2015
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Evaluation of plasma inflammatory cytokine concentrations in racing sled dogs",

abstract = "In human athletes significant changes in cytokine concentrations secondary to exercise have been observed. This prospective study evaluated the effect of a multi-day stage sled dog race on plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). Samples from 20 dogs were harvested prior to and on days 2 and 8 of an 8-day race. Exercise resulted in significantly decreased TNF-α and IL-8 as well as increases of MCP-1, IL-6, and IL-10 concentrations (P-value between 0.01 and < 0.0001 for all parameters). The proportion of values for IL-2 that were below the detection limit increased from 40% on day 0 to 75% on day 2 and decreased on day 8 to 40% (P = 0.04). Racing sled dogs show cytokine-concentration changes that are different from those in humans. ",

author = "{von Pfeil}, {Dirsko J.F.} and Cummings, {Bethany P.} and Loftus, {John P.} and Levine, {Corri B.} and Sabine Mann and Downey, {Robert L.} and Caroline Griffitts and Wakshlag, {Joseph J.}",

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AU - von Pfeil, Dirsko J.F.

AU - Cummings, Bethany P.

AU - Loftus, John P.

AU - Levine, Corri B.

AU - Mann, Sabine

AU - Downey, Robert L.

AU - Griffitts, Caroline

AU - Wakshlag, Joseph J.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - In human athletes significant changes in cytokine concentrations secondary to exercise have been observed. This prospective study evaluated the effect of a multi-day stage sled dog race on plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). Samples from 20 dogs were harvested prior to and on days 2 and 8 of an 8-day race. Exercise resulted in significantly decreased TNF-α and IL-8 as well as increases of MCP-1, IL-6, and IL-10 concentrations (P-value between 0.01 and < 0.0001 for all parameters). The proportion of values for IL-2 that were below the detection limit increased from 40% on day 0 to 75% on day 2 and decreased on day 8 to 40% (P = 0.04). Racing sled dogs show cytokine-concentration changes that are different from those in humans.

AB - In human athletes significant changes in cytokine concentrations secondary to exercise have been observed. This prospective study evaluated the effect of a multi-day stage sled dog race on plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). Samples from 20 dogs were harvested prior to and on days 2 and 8 of an 8-day race. Exercise resulted in significantly decreased TNF-α and IL-8 as well as increases of MCP-1, IL-6, and IL-10 concentrations (P-value between 0.01 and < 0.0001 for all parameters). The proportion of values for IL-2 that were below the detection limit increased from 40% on day 0 to 75% on day 2 and decreased on day 8 to 40% (P = 0.04). Racing sled dogs show cytokine-concentration changes that are different from those in humans.

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Evaluation of plasma inflammatory cytokine concentrations in racing sled dogs

Abstract

ASJC Scopus subject areas

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