Evaluation of Radiological Features of the Posterior Communicating Artery and Their Impact on Efficacy of Saccular Aneurysm Treatment with the Pipeline Embolization Device: A Case Series Study

Alejandro Enriquez-Marulanda, Krishnan Ravindran, Mohamed M. Salem, Luis C. Ascanio, Peter Kan, Visish M. Srinivasan, Christoph J. Griessenauer, Clemens M. Schirmer, Abhi Jain, Justin M. Moore, Christopher S. Ogilvy, Ajith J. Thomas, Abdulrahman Y. Alturki

Research output: Contribution to journalArticle

Abstract

Background: Posterior communicating artery segment aneurysms are one of the most frequent intracranial aneurysms. Currently, limited data have described the use of the pipeline embolization device (PED) in these aneurysms. Methods: We conducted a multicenter retrospective review of 3 prospectively collected databases of patients treated with the PED from January 2013 to December 2017. The primary objective was to assess the efficacy and safety of the PED in the treatment of saccular posterior communicating artery (PComA) aneurysms. We also assessed the effect of anatomical variations on the angiographic and clinical outcomes, including the presence of fetal PComA, vessel origin relationship to the aneurysm, and patency after PED placement. Results: We identified 57 patients with 60 saccular aneurysms; Their mean age was 60.5 years, and 49 were female (86.0%). A total of 55 aneurysms (91.7%) were unruptured. The median imaging follow-up duration was 8.5 months. Complete occlusion at the last imaging follow-up study was 84.0%. At the last follow-up examination, 94.5% of patients had a modified Rankin scale score of ≤2. The presence of fetal PComA, origin type, and patency during follow-up did have a significant effect on aneurysm occlusion (P = 0.61, P = 0.40, and P = 0.14, respectively). Conclusions: PED use for treatment of PComA aneurysms resulted in acceptable occlusion rates. The present study did not find that fetal PComA, its origin, or its patency during follow-up had an effect on aneurysm occlusion.

Original languageEnglish (US)
Pages (from-to)e998-e1007
JournalWorld Neurosurgery
Volume125
DOIs
StatePublished - May 2019
Externally publishedYes

Keywords

  • Anatomy
  • Flow diversion
  • Patency
  • Pipeline embolization device
  • Posterior communicating artery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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    Enriquez-Marulanda, A., Ravindran, K., Salem, M. M., Ascanio, L. C., Kan, P., Srinivasan, V. M., Griessenauer, C. J., Schirmer, C. M., Jain, A., Moore, J. M., Ogilvy, C. S., Thomas, A. J., & Alturki, A. Y. (2019). Evaluation of Radiological Features of the Posterior Communicating Artery and Their Impact on Efficacy of Saccular Aneurysm Treatment with the Pipeline Embolization Device: A Case Series Study. World Neurosurgery, 125, e998-e1007. https://doi.org/10.1016/j.wneu.2019.01.228