Evaluation of the magnitude of the 1993 hantavirus outbreak in the southwestern United States

L. Simonsen, M. J. Dalton, R. F. Breiman, T. Hennessy, E. T. Umland, C. M. Sewell, P. E. Rollin, Thomas Ksiazek, C. J. Peters

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In May 1993, an outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was caused by the previously unrecognized Sin Nombre virus (SNV). Most HPS patients had an influenza-like prodrome, followed by rapid onset of pulmonary edema (fatality rate, 52%). To define the magnitude of the outbreak, patients with milder illnesses who sought medical care in the outbreak area during the outbreak period were assessed for infection with SNV. Of 299 study subjects, 43 had illnesses similar to the HPS prodrome. One laboratory finding, thrombocytopenia, was highly discriminatory between non-HPS patients (1%) and confirmed HPS patients (71%; P < .001) during the prodrome phase. No study subject had serologic evidence (IgM antibodies) of recent SNV infection. Five had IgG liters consistent with a previous hantavirus infection; 3 of these 5 were among the 43 patients who had illnesses similar to the HPS prodrome (P < .05). These data provide evidence that mild illness is rarely caused by SNV.

Original languageEnglish (US)
Pages (from-to)729-733
Number of pages5
JournalJournal of Infectious Diseases
Volume172
Issue number3
StatePublished - 1995
Externally publishedYes

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Hantavirus Pulmonary Syndrome
Southwestern United States
Hantavirus
Sin Nombre virus
Disease Outbreaks
Hantavirus Infections
Virus Diseases
Pulmonary Edema
Thrombocytopenia
Human Influenza
Immunoglobulin M
Immunoglobulin G
Lung
Antibodies
Infection

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Simonsen, L., Dalton, M. J., Breiman, R. F., Hennessy, T., Umland, E. T., Sewell, C. M., ... Peters, C. J. (1995). Evaluation of the magnitude of the 1993 hantavirus outbreak in the southwestern United States. Journal of Infectious Diseases, 172(3), 729-733.

Evaluation of the magnitude of the 1993 hantavirus outbreak in the southwestern United States. / Simonsen, L.; Dalton, M. J.; Breiman, R. F.; Hennessy, T.; Umland, E. T.; Sewell, C. M.; Rollin, P. E.; Ksiazek, Thomas; Peters, C. J.

In: Journal of Infectious Diseases, Vol. 172, No. 3, 1995, p. 729-733.

Research output: Contribution to journalArticle

Simonsen, L, Dalton, MJ, Breiman, RF, Hennessy, T, Umland, ET, Sewell, CM, Rollin, PE, Ksiazek, T & Peters, CJ 1995, 'Evaluation of the magnitude of the 1993 hantavirus outbreak in the southwestern United States', Journal of Infectious Diseases, vol. 172, no. 3, pp. 729-733.
Simonsen L, Dalton MJ, Breiman RF, Hennessy T, Umland ET, Sewell CM et al. Evaluation of the magnitude of the 1993 hantavirus outbreak in the southwestern United States. Journal of Infectious Diseases. 1995;172(3):729-733.
Simonsen, L. ; Dalton, M. J. ; Breiman, R. F. ; Hennessy, T. ; Umland, E. T. ; Sewell, C. M. ; Rollin, P. E. ; Ksiazek, Thomas ; Peters, C. J. / Evaluation of the magnitude of the 1993 hantavirus outbreak in the southwestern United States. In: Journal of Infectious Diseases. 1995 ; Vol. 172, No. 3. pp. 729-733.
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