Evidence for Co-evolution of West Nile Virus and House Sparrows in North America

Nisha K. Duggal, Angela Bosco-Lauth, Richard A. Bowen, Sarah S. Wheeler, William K. Reisen, Todd A. Felix, Brian R. Mann, Hannah Romo, Daniele M. Swetnam, Alan Barrett, Aaron C. Brault

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

West Nile virus (WNV) has been maintained in North America in enzootic cycles between mosquitoes and birds since it was first described in North America in 1999. House sparrows (HOSPs; Passer domesticus) are a highly competent host for WNV that have contributed to the rapid spread of WNV across the U.S.; however, their competence has been evaluated primarily using an early WNV strain (NY99) that is no longer circulating. Herein, we report that the competence of wild HOSPs for the NY99 strain has decreased significantly over time, suggesting that HOSPs may have developed resistance to this early WNV strain. Moreover, recently isolated WNV strains generate higher peak viremias and mortality in contemporary HOSPs compared to NY99. These data indicate that opposing selective pressures in both the virus and avian host have resulted in a net increase in the level of host competence of North American HOSPs for currently circulating WNV strains.

Original languageEnglish (US)
JournalPLoS Neglected Tropical Diseases
Volume8
Issue number10
DOIs
StatePublished - 2014

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Sparrows
West Nile virus
North America
Mental Competency
Viremia
Culicidae
Birds
Viruses
Mortality

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Duggal, N. K., Bosco-Lauth, A., Bowen, R. A., Wheeler, S. S., Reisen, W. K., Felix, T. A., ... Brault, A. C. (2014). Evidence for Co-evolution of West Nile Virus and House Sparrows in North America. PLoS Neglected Tropical Diseases, 8(10). https://doi.org/10.1371/journal.pntd.0003262

Evidence for Co-evolution of West Nile Virus and House Sparrows in North America. / Duggal, Nisha K.; Bosco-Lauth, Angela; Bowen, Richard A.; Wheeler, Sarah S.; Reisen, William K.; Felix, Todd A.; Mann, Brian R.; Romo, Hannah; Swetnam, Daniele M.; Barrett, Alan; Brault, Aaron C.

In: PLoS Neglected Tropical Diseases, Vol. 8, No. 10, 2014.

Research output: Contribution to journalArticle

Duggal, NK, Bosco-Lauth, A, Bowen, RA, Wheeler, SS, Reisen, WK, Felix, TA, Mann, BR, Romo, H, Swetnam, DM, Barrett, A & Brault, AC 2014, 'Evidence for Co-evolution of West Nile Virus and House Sparrows in North America', PLoS Neglected Tropical Diseases, vol. 8, no. 10. https://doi.org/10.1371/journal.pntd.0003262
Duggal, Nisha K. ; Bosco-Lauth, Angela ; Bowen, Richard A. ; Wheeler, Sarah S. ; Reisen, William K. ; Felix, Todd A. ; Mann, Brian R. ; Romo, Hannah ; Swetnam, Daniele M. ; Barrett, Alan ; Brault, Aaron C. / Evidence for Co-evolution of West Nile Virus and House Sparrows in North America. In: PLoS Neglected Tropical Diseases. 2014 ; Vol. 8, No. 10.
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