Evidence for DNA fragmentation in the CNS of aged Fischer-344 rats

Giulio Taglialatela, Matthew Gegg, J. Regiono Perez-Polo, Lawrence R. Williams, Gregory M. Rose

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The aged central nervous system (CNS) is characterized by a loss of neurons. Apoptosis has been reported to be responsible for neuronal death during development and may also be involved in some age-related neurodegenerative diseases of the CNS. No evidence is currently available as to whether apoptosis is also responsible for the loss of neurons associated with physiological aging. In this study, we have found fragmented DNA, a characteristic trait of cells undergoing apoptosis, in the hippocampus and, to a minor extent, in the frontal cortex and basal forebrain of aged (24- month-old) Fisher-344 rats, but not in the cerebellum. These data represent important evidence to support the idea that apoptosis may be associated with the neuronal death observed during normal aging.

Original languageEnglish (US)
Pages (from-to)977-980
Number of pages4
JournalNeuroReport
Volume7
Issue number5
DOIs
StatePublished - Jan 1 1996

    Fingerprint

Keywords

  • Aging
  • Apoptosis
  • Cell death
  • Central nervous system
  • DNA ladder
  • ELISA
  • Hippocampus
  • Neuronal death
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Taglialatela, G., Gegg, M., Regiono Perez-Polo, J., Williams, L. R., & Rose, G. M. (1996). Evidence for DNA fragmentation in the CNS of aged Fischer-344 rats. NeuroReport, 7(5), 977-980. https://doi.org/10.1097/00001756-199604100-00004