Evidence for DNA fragmentation in the CNS of aged Fischer-344 rats

Giulio Taglialatela, Matthew Gegg, J. Regiono Perez-Polo, Lawrence R. Williams, Gregory M. Rose

    Research output: Contribution to journalArticlepeer-review

    38 Scopus citations

    Abstract

    The aged central nervous system (CNS) is characterized by a loss of neurons. Apoptosis has been reported to be responsible for neuronal death during development and may also be involved in some age-related neurodegenerative diseases of the CNS. No evidence is currently available as to whether apoptosis is also responsible for the loss of neurons associated with physiological aging. In this study, we have found fragmented DNA, a characteristic trait of cells undergoing apoptosis, in the hippocampus and, to a minor extent, in the frontal cortex and basal forebrain of aged (24- month-old) Fisher-344 rats, but not in the cerebellum. These data represent important evidence to support the idea that apoptosis may be associated with the neuronal death observed during normal aging.

    Original languageEnglish (US)
    Pages (from-to)977-980
    Number of pages4
    JournalNeuroReport
    Volume7
    Issue number5
    DOIs
    StatePublished - 1996

    Keywords

    • Aging
    • Apoptosis
    • Cell death
    • Central nervous system
    • DNA ladder
    • ELISA
    • Hippocampus
    • Neuronal death
    • Rat

    ASJC Scopus subject areas

    • Neuroscience(all)

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