Evidence for henipavirus spillover into human populations in Africa

Olivier Pernet, Bradley S. Schneider, Shannon M. Beaty, Matthew Lebreton, Tatyana E. Yun, Arnold Park, Trevor T. Zachariah, Thomas A. Bowden, Peta Hitchens, Christina M. Ramirez, Peter Daszak, Jonna Mazet, Alexander Freiberg, Nathan D. Wolfe, Benhur Lee

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reservoirs to humans has only been reported in Australia and South/Southeast Asia. However, a recent study discovered numerous HNV clades in African bat samples. To determine the potential for HNV spillover events among humans in Africa, here we examine well-curated sets of bat (Eidolon helvum, n=44) and human (n=497) serum samples from Cameroon for Nipah virus (NiV) cross-neutralizing antibodies (NiV-X-Nabs). Using a vesicular stomatitis virus (VSV)-based pseudoparticle seroneutralization assay, we detect NiV-X-Nabs in 48% and 3-4% of the bat and human samples, respectively. Seropositive human samples are found almost exclusively in individuals who reported butchering bats for bushmeat. Seropositive human sera also neutralize Hendra virus and Gh-M74a (an African HNV) pseudoparticles, as well as live NiV. Butchering bat meat and living in areas undergoing deforestation are the most significant risk factors associated with seropositivity. Evidence for HNV spillover events warrants increased surveillance efforts.

Original languageEnglish (US)
Article number5342
JournalNature Communications
Volume5
DOIs
StatePublished - 2014

Fingerprint

Henipavirus
bats
viruses
Nipah Virus
Viruses
Population
serums
Hendra Virus
Cameroon
deforestation
Southeast Asia
Deforestation
Southeastern Asia
Vesicular Stomatitis
South Australia
fruits
Meats
Conservation of Natural Resources
Zoonoses
surveillance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Pernet, O., Schneider, B. S., Beaty, S. M., Lebreton, M., Yun, T. E., Park, A., ... Lee, B. (2014). Evidence for henipavirus spillover into human populations in Africa. Nature Communications, 5, [5342]. https://doi.org/10.1038/ncomms6342

Evidence for henipavirus spillover into human populations in Africa. / Pernet, Olivier; Schneider, Bradley S.; Beaty, Shannon M.; Lebreton, Matthew; Yun, Tatyana E.; Park, Arnold; Zachariah, Trevor T.; Bowden, Thomas A.; Hitchens, Peta; Ramirez, Christina M.; Daszak, Peter; Mazet, Jonna; Freiberg, Alexander; Wolfe, Nathan D.; Lee, Benhur.

In: Nature Communications, Vol. 5, 5342, 2014.

Research output: Contribution to journalArticle

Pernet, O, Schneider, BS, Beaty, SM, Lebreton, M, Yun, TE, Park, A, Zachariah, TT, Bowden, TA, Hitchens, P, Ramirez, CM, Daszak, P, Mazet, J, Freiberg, A, Wolfe, ND & Lee, B 2014, 'Evidence for henipavirus spillover into human populations in Africa', Nature Communications, vol. 5, 5342. https://doi.org/10.1038/ncomms6342
Pernet O, Schneider BS, Beaty SM, Lebreton M, Yun TE, Park A et al. Evidence for henipavirus spillover into human populations in Africa. Nature Communications. 2014;5. 5342. https://doi.org/10.1038/ncomms6342
Pernet, Olivier ; Schneider, Bradley S. ; Beaty, Shannon M. ; Lebreton, Matthew ; Yun, Tatyana E. ; Park, Arnold ; Zachariah, Trevor T. ; Bowden, Thomas A. ; Hitchens, Peta ; Ramirez, Christina M. ; Daszak, Peter ; Mazet, Jonna ; Freiberg, Alexander ; Wolfe, Nathan D. ; Lee, Benhur. / Evidence for henipavirus spillover into human populations in Africa. In: Nature Communications. 2014 ; Vol. 5.
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