Abstract
Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reservoirs to humans has only been reported in Australia and South/Southeast Asia. However, a recent study discovered numerous HNV clades in African bat samples. To determine the potential for HNV spillover events among humans in Africa, here we examine well-curated sets of bat (Eidolon helvum, n=44) and human (n=497) serum samples from Cameroon for Nipah virus (NiV) cross-neutralizing antibodies (NiV-X-Nabs). Using a vesicular stomatitis virus (VSV)-based pseudoparticle seroneutralization assay, we detect NiV-X-Nabs in 48% and 3-4% of the bat and human samples, respectively. Seropositive human samples are found almost exclusively in individuals who reported butchering bats for bushmeat. Seropositive human sera also neutralize Hendra virus and Gh-M74a (an African HNV) pseudoparticles, as well as live NiV. Butchering bat meat and living in areas undergoing deforestation are the most significant risk factors associated with seropositivity. Evidence for HNV spillover events warrants increased surveillance efforts.
| Original language | English (US) |
|---|---|
| Article number | 5342 |
| Journal | Nature Communications |
| Volume | 5 |
| DOIs | |
| State | Published - 2014 |
Fingerprint
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Chemistry(all)
- Physics and Astronomy(all)
Cite this
Evidence for henipavirus spillover into human populations in Africa. / Pernet, Olivier; Schneider, Bradley S.; Beaty, Shannon M.; Lebreton, Matthew; Yun, Tatyana E.; Park, Arnold; Zachariah, Trevor T.; Bowden, Thomas A.; Hitchens, Peta; Ramirez, Christina M.; Daszak, Peter; Mazet, Jonna; Freiberg, Alexander; Wolfe, Nathan D.; Lee, Benhur.
In: Nature Communications, Vol. 5, 5342, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evidence for henipavirus spillover into human populations in Africa
AU - Pernet, Olivier
AU - Schneider, Bradley S.
AU - Beaty, Shannon M.
AU - Lebreton, Matthew
AU - Yun, Tatyana E.
AU - Park, Arnold
AU - Zachariah, Trevor T.
AU - Bowden, Thomas A.
AU - Hitchens, Peta
AU - Ramirez, Christina M.
AU - Daszak, Peter
AU - Mazet, Jonna
AU - Freiberg, Alexander
AU - Wolfe, Nathan D.
AU - Lee, Benhur
PY - 2014
Y1 - 2014
N2 - Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reservoirs to humans has only been reported in Australia and South/Southeast Asia. However, a recent study discovered numerous HNV clades in African bat samples. To determine the potential for HNV spillover events among humans in Africa, here we examine well-curated sets of bat (Eidolon helvum, n=44) and human (n=497) serum samples from Cameroon for Nipah virus (NiV) cross-neutralizing antibodies (NiV-X-Nabs). Using a vesicular stomatitis virus (VSV)-based pseudoparticle seroneutralization assay, we detect NiV-X-Nabs in 48% and 3-4% of the bat and human samples, respectively. Seropositive human samples are found almost exclusively in individuals who reported butchering bats for bushmeat. Seropositive human sera also neutralize Hendra virus and Gh-M74a (an African HNV) pseudoparticles, as well as live NiV. Butchering bat meat and living in areas undergoing deforestation are the most significant risk factors associated with seropositivity. Evidence for HNV spillover events warrants increased surveillance efforts.
AB - Zoonotic transmission of lethal henipaviruses (HNVs) from their natural fruit bat reservoirs to humans has only been reported in Australia and South/Southeast Asia. However, a recent study discovered numerous HNV clades in African bat samples. To determine the potential for HNV spillover events among humans in Africa, here we examine well-curated sets of bat (Eidolon helvum, n=44) and human (n=497) serum samples from Cameroon for Nipah virus (NiV) cross-neutralizing antibodies (NiV-X-Nabs). Using a vesicular stomatitis virus (VSV)-based pseudoparticle seroneutralization assay, we detect NiV-X-Nabs in 48% and 3-4% of the bat and human samples, respectively. Seropositive human samples are found almost exclusively in individuals who reported butchering bats for bushmeat. Seropositive human sera also neutralize Hendra virus and Gh-M74a (an African HNV) pseudoparticles, as well as live NiV. Butchering bat meat and living in areas undergoing deforestation are the most significant risk factors associated with seropositivity. Evidence for HNV spillover events warrants increased surveillance efforts.
UR - http://www.scopus.com/inward/record.url?scp=84920794111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920794111&partnerID=8YFLogxK
U2 - 10.1038/ncomms6342
DO - 10.1038/ncomms6342
M3 - Article
C2 - 25405640
AN - SCOPUS:84920794111
VL - 5
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 5342
ER -