Evidence for regulation of peptide-yy release by the proximal gut

George H Greeley, Yow Jiun Jeng, Guillermo Gomez, Tsukuru Hashimoto, Freddie L.C. Hill, Kyle Kern, Tanya Kurosky, Hsiao Fen Chuo, James C. Thompson

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

Peptide-YY (PYY) is a novel enteric peptide that is structurally related to pancreatic polypeptide and neuropeptide- Y. the objectives of the present experiments were to characterize the following aspects of PYY metabolism: The distribution of PYY in the canine gastrointestinal tract, the release of PYY in response to oral ingestion of a mixed meal or intraduodenal (ID) administration of oleic acid, the effect of ileocolectomy on the release of PYY in response to ID administration of oleic acid when transit of chyme to the distal ileum and colon is prevented, the effect of interruption of intramural neural pathways of the small bowel on the release of PYY, and the effect of iv cholecystokinin on the release of PYY. the results of these experiments demonstrate that PYY immunoreactivity is distributed primarily in the terminal ileum, colon, and rectum. Circulating levels of PYY increase significantly (P < 0.05) within 10-30 min after ingestion of a meal or to ID administration of a fatty acid. Complete interruption of the flow of chyme to the site of PYY-containing cells (i.e. ileum-colon) did not block the release of PYY; however, ileocolectomy abolished the release of PYY in response to ID administration of oleic acid. Severance of intramural neural pathways along the small bowel did not alter the release of PYY in response to an oral meal. Intravenous administration of graded doses of cholecystokinin stimulated the release of PYY in a dose-related manner. the results of these experiments indicate that the release of PYY from the distal ileum and colon is controlled, at least in part, by an extramural neural, endocrine, or a combination of both types of mechanisms which originate in the foregut.

Original languageEnglish (US)
Pages (from-to)1438-1443
Number of pages6
JournalEndocrinology
Volume124
Issue number3
DOIs
StatePublished - Mar 1989

ASJC Scopus subject areas

  • Endocrinology

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