Evidence for unmyelinated sensory fibres in the posterior columns in man

Rudy P. Briner, Susan M. Carlton, Richard E. Coggeshall, Kyungsoon Chung

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The human posterior columns are generally described as a myelinated fibre pathway. The present study demonstrates that more than 25% of the component axons are unmyelinated. Many of these unmyelinated axons are labelled by antibodies to calcitonin gene-related peptide (CGRP), a substance found in sensory cells, axons and terminals. On this basis we suggest that there are significant numbers of unmyelinated primary afferent axons in the human posterior columns. These results indicate that unmyelinated sensory axons are more widespread than previously thought, and that they should be taken into account when considering stimulation of the posterior columns to relieve pain.

Original languageEnglish (US)
Pages (from-to)999-1007
Number of pages9
JournalBrain
Volume111
Issue number5
DOIs
StatePublished - Oct 1988

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axons
Axons
Fiber
Fibers
Pain
Antibody
Peptides
Calcitonin Gene-Related Peptide
Pathway
Presynaptic Terminals
Gene
Antibodies
Cell
pain
Demonstrate
Evidence
antibodies
Human
cells

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Briner, R. P., Carlton, S. M., Coggeshall, R. E., & Chung, K. (1988). Evidence for unmyelinated sensory fibres in the posterior columns in man. Brain, 111(5), 999-1007. https://doi.org/10.1093/brain/111.5.999

Evidence for unmyelinated sensory fibres in the posterior columns in man. / Briner, Rudy P.; Carlton, Susan M.; Coggeshall, Richard E.; Chung, Kyungsoon.

In: Brain, Vol. 111, No. 5, 10.1988, p. 999-1007.

Research output: Contribution to journalArticle

Briner, RP, Carlton, SM, Coggeshall, RE & Chung, K 1988, 'Evidence for unmyelinated sensory fibres in the posterior columns in man', Brain, vol. 111, no. 5, pp. 999-1007. https://doi.org/10.1093/brain/111.5.999
Briner, Rudy P. ; Carlton, Susan M. ; Coggeshall, Richard E. ; Chung, Kyungsoon. / Evidence for unmyelinated sensory fibres in the posterior columns in man. In: Brain. 1988 ; Vol. 111, No. 5. pp. 999-1007.
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