TY - JOUR
T1 - Evidence of natural Zika virus infection in neotropical non-human primates in Brazil
AU - Terzian, Ana Carolina B.
AU - Zini, Nathalia
AU - Sacchetto, Lívia
AU - Rocha, Rebeca Froes
AU - Parra, Maisa Carla Pereira
AU - Del Sarto, Juliana Lemos
AU - Dias, Ana Carolina Fialho
AU - Coutinho, Felipe
AU - Rayra, Jéssica
AU - da Silva, Rafael Alves
AU - Costa, Vivian Vasconcelos
AU - Fernandes, Natália Coelho Couto De Azevedo
AU - Réssio, Rodrigo
AU - Díaz-Delgado, Josué
AU - Guerra, Juliana
AU - Cunha, Mariana S.
AU - Catão-Dias, José Luiz
AU - Bittar, Cintia
AU - Reis, Andréia Francesli Negri
AU - Santos, Izalco Nuremberg Penha dos
AU - Ferreira, Andréia Cristina Marascalchi
AU - Cruz, Lilian Elisa Arão Antônio
AU - Rahal, Paula
AU - Ullmann, Leila
AU - Malossi, Camila
AU - Araújo, João Pessoa de
AU - Widen, Steven
AU - de Rezende, Izabela Maurício
AU - Mello, Érica
AU - Pacca, Carolina Colombelli
AU - Kroon, Erna Geessien
AU - Trindade, Giliane
AU - Drumond, Betânia
AU - Chiaravalloti-Neto, Francisco
AU - Vasilakis, Nikos
AU - Teixeira, Mauro M.
AU - Nogueira, Maurício Lacerda
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.
AB - In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.
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U2 - 10.1038/s41598-018-34423-6
DO - 10.1038/s41598-018-34423-6
M3 - Article
C2 - 30375482
AN - SCOPUS:85055615937
SN - 2045-2322
VL - 8
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 16034
ER -