Evidence of natural Zika virus infection in neotropical non-human primates in Brazil

Ana Carolina B. Terzian, Nathalia Zini, Lívia Sacchetto, Rebeca Froes Rocha, Maisa Carla Pereira Parra, Juliana Lemos Del Sarto, Ana Carolina Fialho Dias, Felipe Coutinho, Jéssica Rayra, Rafael Alves da Silva, Vivian Vasconcelos Costa, Natália Coelho Couto De Azevedo Fernandes, Rodrigo Réssio, Josué Díaz-Delgado, Juliana Guerra, Mariana S. Cunha, José Luiz Catão-Dias, Cintia Bittar, Andréia Francesli Negri Reis, Izalco Nuremberg Penha dos SantosAndréia Cristina Marascalchi Ferreira, Lilian Elisa Arão Antônio Cruz, Paula Rahal, Leila Ullmann, Camila Malossi, João Pessoa de Araújo, Steven Widen, Izabela Maurício de Rezende, Érica Mello, Carolina Colombelli Pacca, Erna Geessien Kroon, Giliane Trindade, Betânia Drumond, Francisco Chiaravalloti-Neto, Nikos Vasilakis, Mauro M. Teixeira, Maurício Lacerda Nogueira

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.

Original languageEnglish (US)
Article number16034
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Primates
Brazil
Callithrix
Latin America
Viremia
Vertebrates
Maintenance
Infection
Zika Virus Infection

ASJC Scopus subject areas

  • General

Cite this

Terzian, A. C. B., Zini, N., Sacchetto, L., Rocha, R. F., Parra, M. C. P., Del Sarto, J. L., ... Nogueira, M. L. (2018). Evidence of natural Zika virus infection in neotropical non-human primates in Brazil. Scientific Reports, 8(1), [16034]. https://doi.org/10.1038/s41598-018-34423-6

Evidence of natural Zika virus infection in neotropical non-human primates in Brazil. / Terzian, Ana Carolina B.; Zini, Nathalia; Sacchetto, Lívia; Rocha, Rebeca Froes; Parra, Maisa Carla Pereira; Del Sarto, Juliana Lemos; Dias, Ana Carolina Fialho; Coutinho, Felipe; Rayra, Jéssica; da Silva, Rafael Alves; Costa, Vivian Vasconcelos; Fernandes, Natália Coelho Couto De Azevedo; Réssio, Rodrigo; Díaz-Delgado, Josué; Guerra, Juliana; Cunha, Mariana S.; Catão-Dias, José Luiz; Bittar, Cintia; Reis, Andréia Francesli Negri; Santos, Izalco Nuremberg Penha dos; Ferreira, Andréia Cristina Marascalchi; Cruz, Lilian Elisa Arão Antônio; Rahal, Paula; Ullmann, Leila; Malossi, Camila; Araújo, João Pessoa de; Widen, Steven; de Rezende, Izabela Maurício; Mello, Érica; Pacca, Carolina Colombelli; Kroon, Erna Geessien; Trindade, Giliane; Drumond, Betânia; Chiaravalloti-Neto, Francisco; Vasilakis, Nikos; Teixeira, Mauro M.; Nogueira, Maurício Lacerda.

In: Scientific Reports, Vol. 8, No. 1, 16034, 01.12.2018.

Research output: Contribution to journalArticle

Terzian, ACB, Zini, N, Sacchetto, L, Rocha, RF, Parra, MCP, Del Sarto, JL, Dias, ACF, Coutinho, F, Rayra, J, da Silva, RA, Costa, VV, Fernandes, NCCDA, Réssio, R, Díaz-Delgado, J, Guerra, J, Cunha, MS, Catão-Dias, JL, Bittar, C, Reis, AFN, Santos, INPD, Ferreira, ACM, Cruz, LEAA, Rahal, P, Ullmann, L, Malossi, C, Araújo, JPD, Widen, S, de Rezende, IM, Mello, É, Pacca, CC, Kroon, EG, Trindade, G, Drumond, B, Chiaravalloti-Neto, F, Vasilakis, N, Teixeira, MM & Nogueira, ML 2018, 'Evidence of natural Zika virus infection in neotropical non-human primates in Brazil', Scientific Reports, vol. 8, no. 1, 16034. https://doi.org/10.1038/s41598-018-34423-6
Terzian ACB, Zini N, Sacchetto L, Rocha RF, Parra MCP, Del Sarto JL et al. Evidence of natural Zika virus infection in neotropical non-human primates in Brazil. Scientific Reports. 2018 Dec 1;8(1). 16034. https://doi.org/10.1038/s41598-018-34423-6
Terzian, Ana Carolina B. ; Zini, Nathalia ; Sacchetto, Lívia ; Rocha, Rebeca Froes ; Parra, Maisa Carla Pereira ; Del Sarto, Juliana Lemos ; Dias, Ana Carolina Fialho ; Coutinho, Felipe ; Rayra, Jéssica ; da Silva, Rafael Alves ; Costa, Vivian Vasconcelos ; Fernandes, Natália Coelho Couto De Azevedo ; Réssio, Rodrigo ; Díaz-Delgado, Josué ; Guerra, Juliana ; Cunha, Mariana S. ; Catão-Dias, José Luiz ; Bittar, Cintia ; Reis, Andréia Francesli Negri ; Santos, Izalco Nuremberg Penha dos ; Ferreira, Andréia Cristina Marascalchi ; Cruz, Lilian Elisa Arão Antônio ; Rahal, Paula ; Ullmann, Leila ; Malossi, Camila ; Araújo, João Pessoa de ; Widen, Steven ; de Rezende, Izabela Maurício ; Mello, Érica ; Pacca, Carolina Colombelli ; Kroon, Erna Geessien ; Trindade, Giliane ; Drumond, Betânia ; Chiaravalloti-Neto, Francisco ; Vasilakis, Nikos ; Teixeira, Mauro M. ; Nogueira, Maurício Lacerda. / Evidence of natural Zika virus infection in neotropical non-human primates in Brazil. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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abstract = "In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America.",
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AU - Sacchetto, Lívia

AU - Rocha, Rebeca Froes

AU - Parra, Maisa Carla Pereira

AU - Del Sarto, Juliana Lemos

AU - Dias, Ana Carolina Fialho

AU - Coutinho, Felipe

AU - Rayra, Jéssica

AU - da Silva, Rafael Alves

AU - Costa, Vivian Vasconcelos

AU - Fernandes, Natália Coelho Couto De Azevedo

AU - Réssio, Rodrigo

AU - Díaz-Delgado, Josué

AU - Guerra, Juliana

AU - Cunha, Mariana S.

AU - Catão-Dias, José Luiz

AU - Bittar, Cintia

AU - Reis, Andréia Francesli Negri

AU - Santos, Izalco Nuremberg Penha dos

AU - Ferreira, Andréia Cristina Marascalchi

AU - Cruz, Lilian Elisa Arão Antônio

AU - Rahal, Paula

AU - Ullmann, Leila

AU - Malossi, Camila

AU - Araújo, João Pessoa de

AU - Widen, Steven

AU - de Rezende, Izabela Maurício

AU - Mello, Érica

AU - Pacca, Carolina Colombelli

AU - Kroon, Erna Geessien

AU - Trindade, Giliane

AU - Drumond, Betânia

AU - Chiaravalloti-Neto, Francisco

AU - Vasilakis, Nikos

AU - Teixeira, Mauro M.

AU - Nogueira, Maurício Lacerda

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