Evolution and dispersal of St. Louis encephalitis virus in the Americas

Albert J. Auguste, Oliver G. Pybus, C. V F Carrington

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Using a Bayesian coalescent approach on a dataset of 73 envelope gene sequences we estimated substitution rates and dates of divergence for St. Louis encephalitis virus (SLEV) in the Americas. We found significant rate heterogeneity among lineages, such that "relaxed" molecular clock models were much better supported than a strict molecular clock. The mean substitution rate estimated for all SLEV was 4.1 × 10-4 substitutions/site/year (95% HPD 2.5-5.7)-higher than previous estimates that relied on the less well-suited strict clock. Mean substitution rates for individual lineages varied from 3.7 × 10-4 to 7.2 × 10-4 substitutions/site/year. For the first time we also assessed the magnitude and direction of viral gene flow within the Americas. The overall direction of gene flow during the period represented by the phylogeny is from South to North, and the region between 15°N and 30°N latitude appears to be the major source of virus for the rest of North America, which is consistent with migratory birds returning to their northern breeding grounds having acquired infection while wintering in the region of the Gulf of Mexico.

Original languageEnglish (US)
Pages (from-to)709-715
Number of pages7
JournalInfection, Genetics and Evolution
Volume9
Issue number4
DOIs
StatePublished - Jul 2009
Externally publishedYes

Fingerprint

St. Louis Encephalitis Viruses
Saint Louis encephalitis virus
encephalitis
Gene Flow
gene flow
virus
substitution
Gulf of Mexico region
Gulf of Mexico
Molecular Models
Bayes Theorem
Viral Genes
Phylogeny
North America
breeding sites
Birds
Breeding
Viruses
nucleotide sequences
viruses

Keywords

  • Flavivirus
  • Gene flow
  • Molecular evolution
  • Most recent common ancestor
  • Phylogeography
  • Relaxed molecular clock
  • St. Louis encephalitis virus
  • Substitution rate

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Microbiology
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Evolution and dispersal of St. Louis encephalitis virus in the Americas. / Auguste, Albert J.; Pybus, Oliver G.; Carrington, C. V F.

In: Infection, Genetics and Evolution, Vol. 9, No. 4, 07.2009, p. 709-715.

Research output: Contribution to journalArticle

Auguste, Albert J. ; Pybus, Oliver G. ; Carrington, C. V F. / Evolution and dispersal of St. Louis encephalitis virus in the Americas. In: Infection, Genetics and Evolution. 2009 ; Vol. 9, No. 4. pp. 709-715.
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