Evolution and epidemiology of diarrheagenic escherichia coli

Nina D. Williams, Alfredo Torres, Sonja J. Lloyd

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

The emergence and evolution of pathogenic Escherichia coli strains associated with diarrheal diseases have become a topic of active investigation in recent years due to the emergence of more virulent strains and the association of new serotypes with disease. Outbreak studies indicate that most patients with an intestinal E. coli infection develop mild, uncomplicated diarrhea. However, a significant risk exists that infections caused by highly virulent E. coli isolates, such as the enterohemorrhagic E. coli O157:H7, develop into serious and potentially lifethreatening complications, such as hemolytic uremic syndrome. The relative contribution of recombination events in the generation of new categories of pathogenic E. coli varies among the E. coli population, and it is represented by the wide variety of mobile elements found in different diarrheal strains (e.g. pathogenicity islands, phages, transposons, pathoadaptive mutations, etc). Understanding the population structure of pathogenic E. coli is important, since it impacts the effectiveness of molecular epidemiological studies. Such studies are needed to understand the increasingly recognized diversity of enterotoxigenic E. coli, a leading cause of pediatric and travelers' diarrhea. In addition, factors underlying the emergence of enteroaggregative and atypical enteropathogenic E. coli strains associated with persistent diarrhea are unknown. Horizontal transfer of genetic elements that affect virulence of diarrheagenic E. coli strains and changes in global agricultural processes, as well as movement of humans and animals, may contribute to the complex natural history of diarrheagenic E. coli.

Original languageEnglish (US)
Title of host publicationPathogenic Escherichia coli in Latin America
PublisherBentham Science Publishers Ltd.
Pages8-24
Number of pages17
ISBN (Print)9781608055715
DOIs
StatePublished - 2010

Fingerprint

Epidemiology
Escherichia coli
Diarrhea
Enterohemorrhagic Escherichia coli
Genomic Islands
Enterotoxigenic Escherichia coli
Enteropathogenic Escherichia coli
Escherichia coli Infections
Hemolytic-Uremic Syndrome
Escherichia coli O157
Natural History
Bacteriophages
Genetic Recombination
Population
Disease Outbreaks
Virulence
Epidemiologic Studies
Pediatrics
Mutation
Animals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Williams, N. D., Torres, A., & Lloyd, S. J. (2010). Evolution and epidemiology of diarrheagenic escherichia coli. In Pathogenic Escherichia coli in Latin America (pp. 8-24). Bentham Science Publishers Ltd.. https://doi.org/10.2174/978160805192211001010008

Evolution and epidemiology of diarrheagenic escherichia coli. / Williams, Nina D.; Torres, Alfredo; Lloyd, Sonja J.

Pathogenic Escherichia coli in Latin America. Bentham Science Publishers Ltd., 2010. p. 8-24.

Research output: Chapter in Book/Report/Conference proceedingChapter

Williams, ND, Torres, A & Lloyd, SJ 2010, Evolution and epidemiology of diarrheagenic escherichia coli. in Pathogenic Escherichia coli in Latin America. Bentham Science Publishers Ltd., pp. 8-24. https://doi.org/10.2174/978160805192211001010008
Williams ND, Torres A, Lloyd SJ. Evolution and epidemiology of diarrheagenic escherichia coli. In Pathogenic Escherichia coli in Latin America. Bentham Science Publishers Ltd. 2010. p. 8-24 https://doi.org/10.2174/978160805192211001010008
Williams, Nina D. ; Torres, Alfredo ; Lloyd, Sonja J. / Evolution and epidemiology of diarrheagenic escherichia coli. Pathogenic Escherichia coli in Latin America. Bentham Science Publishers Ltd., 2010. pp. 8-24
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