TY - JOUR
T1 - Evolution of LDL-C lowering medications and their cardiovascular benefits
T2 - Past, present, and future
AU - Faluk, Mohammed
AU - Wardhere, Abdirahman
AU - Mohamoud, Abdilahi
AU - Nor, Mohammed
AU - Bampastsias, Dimitrios
AU - Oikonomou, Ermioni
AU - Almubaid, Zaid
AU - Al-Hemyari, Bashar
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2024/7
Y1 - 2024/7
N2 - Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Hyperlipidemia, particularly elevated low-density lipoprotein cholesterol (LDL-C) is one of the major risk factors for CVD. Major landmark cardiovascular outcome clinical trials demonstrated that LDL-C lowering medications reduce cardiovascular events, and the lower the LDL-C the better the outcome. This article discusses the evolution of LDL-C lowering medications starting from bile acid sequestrants (BAS), statin therapy, bempedoic acid, the proprotein convertase subtilisin kexin 9 (PCSK9) synthesis inhibitor, novel small interfering RNA-based therapy (inclisiran) to the most recent oral PCSK9 inhibitors (MK-0616) which is currently under phase 3 clinical trial studies.
AB - Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Hyperlipidemia, particularly elevated low-density lipoprotein cholesterol (LDL-C) is one of the major risk factors for CVD. Major landmark cardiovascular outcome clinical trials demonstrated that LDL-C lowering medications reduce cardiovascular events, and the lower the LDL-C the better the outcome. This article discusses the evolution of LDL-C lowering medications starting from bile acid sequestrants (BAS), statin therapy, bempedoic acid, the proprotein convertase subtilisin kexin 9 (PCSK9) synthesis inhibitor, novel small interfering RNA-based therapy (inclisiran) to the most recent oral PCSK9 inhibitors (MK-0616) which is currently under phase 3 clinical trial studies.
KW - Cardiovascular benefits
KW - Cholesterol medications
KW - LDL-C lowering medications
KW - LDL-C medications
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U2 - 10.1016/j.cpcardiol.2024.102637
DO - 10.1016/j.cpcardiol.2024.102637
M3 - Review article
C2 - 38735347
AN - SCOPUS:85193997462
SN - 0146-2806
VL - 49
SP - 102637
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 7
M1 - 102637
ER -