Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

Albert J. Auguste; Jonathan Liria; Naomi L. Forrester; Dileyvic Giambalvo; Maria Moncada; Kanya C. Long; Dulce Morón; Nuris de Manzione; Robert B. Tesh; Eric S. Halsey; Tadeusz J. Kochel; Rosa Hernandez; Juan Carlos Navarro; Scott C. Weaver

doi:10.3201/eid2110.141660

Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

Albert J. Auguste, Jonathan Liria, Naomi L. Forrester, Dileyvic Giambalvo, Maria Moncada, Kanya C. Long, Dulce Morón, Nuris de Manzione, Robert B. Tesh, Eric S. Halsey, Tadeusz J. Kochel, Rosa Hernandez, Juan Carlos Navarro, Scott C. Weaver

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107 Scopus citations

Abstract

In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.

Original language	English (US)
Pages (from-to)	1742-1750
Number of pages	9
Journal	Emerging infectious diseases
Volume	21
Issue number	10
DOIs	https://doi.org/10.3201/eid2110.141660
State	Published - Sep 1 2015

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Auguste, A. J., Liria, J., Forrester, N. L., Giambalvo, D., Moncada, M., Long, K. C., Morón, D., de Manzione, N., Tesh, R. B., Halsey, E. S., Kochel, T. J., Hernandez, R., Navarro, J. C., & Weaver, S. C. (2015). Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010. Emerging infectious diseases, 21(10), 1742-1750. https://doi.org/10.3201/eid2110.141660

Auguste, AJ, Liria, J, Forrester, NL, Giambalvo, D, Moncada, M, Long, KC, Morón, D, de Manzione, N, Tesh, RB, Halsey, ES, Kochel, TJ, Hernandez, R, Navarro, JC & Weaver, SC 2015, 'Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010', Emerging infectious diseases, vol. 21, no. 10, pp. 1742-1750. https://doi.org/10.3201/eid2110.141660

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abstract = "In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estaci{\'o}n village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.",

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AU - de Manzione, Nuris

AU - Tesh, Robert B.

AU - Halsey, Eric S.

AU - Kochel, Tadeusz J.

AU - Hernandez, Rosa

AU - Navarro, Juan Carlos

AU - Weaver, Scott C.

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AB - In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.

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Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

Abstract

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