Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010

Albert J. Auguste, Jonathan Liria, Naomi L. Forrester, Dileyvic Giambalvo, Maria Moncada, Kanya C. Long, Dulce Morón, Nuris de Manzione, Robert B. Tesh, Eric S. Halsey, Tadeusz J. Kochel, Rosa Hernandez, Juan Carlos Navarro, Scott Weaver

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

In 2010, an outbreak of febrile illness with arthralgic manifestations was detected at La Estación village, Portuguesa State, Venezuela. The etiologic agent was determined to be Mayaro virus (MAYV), a reemerging South American alphavirus. A total of 77 cases was reported and 19 were confirmed as seropositive. MAYV was isolated from acutephase serum samples from 6 symptomatic patients. We sequenced 27 complete genomes representing the full spectrum of MAYV genetic diversity, which facilitated detection of a new genotype, designated N. Phylogenetic analysis of genomic sequences indicated that etiologic strains from Venezuela belong to genotype D. Results indicate that MAYV is highly conserved genetically, showing ≈17% nucleotide divergence across all 3 genotypes and 4% among genotype D strains in the most variable genes. Coalescent analyses suggested genotypes D and L diverged ≈150 years ago and genotype diverged N ≈250 years ago. This virus commonly infects persons residing near enzootic transmission foci because of anthropogenic incursions.

Original languageEnglish (US)
Pages (from-to)1742-1750
Number of pages9
JournalEmerging Infectious Diseases
Volume21
Issue number10
DOIs
StatePublished - Sep 1 2015

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Venezuela
Disease Outbreaks
Genotype
Viruses
Alphavirus
Sequence Analysis
Fever
Nucleotides
Genome
Serum
Genes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010. / Auguste, Albert J.; Liria, Jonathan; Forrester, Naomi L.; Giambalvo, Dileyvic; Moncada, Maria; Long, Kanya C.; Morón, Dulce; de Manzione, Nuris; Tesh, Robert B.; Halsey, Eric S.; Kochel, Tadeusz J.; Hernandez, Rosa; Navarro, Juan Carlos; Weaver, Scott.

In: Emerging Infectious Diseases, Vol. 21, No. 10, 01.09.2015, p. 1742-1750.

Research output: Contribution to journalArticle

Auguste, AJ, Liria, J, Forrester, NL, Giambalvo, D, Moncada, M, Long, KC, Morón, D, de Manzione, N, Tesh, RB, Halsey, ES, Kochel, TJ, Hernandez, R, Navarro, JC & Weaver, S 2015, 'Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010', Emerging Infectious Diseases, vol. 21, no. 10, pp. 1742-1750. https://doi.org/10.3201/eid2110.141660
Auguste, Albert J. ; Liria, Jonathan ; Forrester, Naomi L. ; Giambalvo, Dileyvic ; Moncada, Maria ; Long, Kanya C. ; Morón, Dulce ; de Manzione, Nuris ; Tesh, Robert B. ; Halsey, Eric S. ; Kochel, Tadeusz J. ; Hernandez, Rosa ; Navarro, Juan Carlos ; Weaver, Scott. / Evolutionary and ecological characterization of mayaro virus strains isolated during an outbreak, Venezuela, 2010. In: Emerging Infectious Diseases. 2015 ; Vol. 21, No. 10. pp. 1742-1750.
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