Evolutionary and ecological factors underlying the tempo and distribution of yellow fever virus activity

Christine V F Carrington, Albert J. Auguste

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Yellow fever virus (YFV) is historically one of the most important viruses to affect human populations. Despite the existence of highly effective vaccines for over 70. years, yellow fever remains a significant and re-emerging cause of morbidity and mortality in endemic and high-risk regions of South America and Africa. The virus may be maintained in sylvatic enzootic/epizootic, transitional and urban epidemic transmission cycles with geographic variation in terms of levels of genetic diversity, the nature of transmission cycles and patterns of outbreak activity. In this review we consider evolutionary and ecological factors underlying YFV emergence, maintenance and spread, geographic distribution and patterns of epizootic/epidemic activity.

Original languageEnglish (US)
Pages (from-to)198-210
Number of pages13
JournalInfection, Genetics and Evolution
Volume13
Issue number1
DOIs
StatePublished - Jan 2013

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Yellow fever virus
yellow fever
virus
Viruses
Yellow Fever
South America
South Africa
Disease Outbreaks
viruses
Vaccines
Maintenance
Morbidity
geographical variation
human population
morbidity
Mortality
geographical distribution
vaccine
vaccines
Population

Keywords

  • Evolution
  • Geographic distribution
  • Phylogeny
  • Phylogeography
  • Yellow fever virus

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Microbiology
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Evolutionary and ecological factors underlying the tempo and distribution of yellow fever virus activity. / Carrington, Christine V F; Auguste, Albert J.

In: Infection, Genetics and Evolution, Vol. 13, No. 1, 01.2013, p. 198-210.

Research output: Contribution to journalArticle

Carrington, Christine V F ; Auguste, Albert J. / Evolutionary and ecological factors underlying the tempo and distribution of yellow fever virus activity. In: Infection, Genetics and Evolution. 2013 ; Vol. 13, No. 1. pp. 198-210.
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