Evolutionary processes among sylvatic dengue type 2 viruses

Nikos Vasilakis, Edward C. Holmes, Eric B. Fokam, Ousmane Faye, Mawlouth Diallo, Amadou A. Sall, Scott Weaver

Research output: Contribution to journalArticle

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Abstract

Sylvatic dengue viruses (DENV) are transmitted in an enzootic cycle between nonhuman primates and arboreal Aedes mosquitoes in Southeast Asia and West Africa. Although previous analyses have revealed the evolutionary processes among endemic (human) DENV, little is known about viral evolution in the sylvatic cycle. Through an analysis of 14 complete coding regions of sylvatic Dengue type 2 virus sampled over a 33-year period, we show that both the rate of evolutionary change and the pattern of natural selection are similar among endemic and sylvatic DENV, although the latter have a uniquely high frequency of positive selection in the NS4B protein gene. Our findings support a recent cross-species transmission event and suggest the possibility of future DENV reemergence from the sylvatic cycle.

Original languageEnglish (US)
Pages (from-to)9591-9595
Number of pages5
JournalJournal of Virology
Volume81
Issue number17
DOIs
StatePublished - Sep 2007

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Dengue virus
Dengue Virus
Southeastern Asia
Western Africa
Aedes
Genetic Selection
Culicidae
South East Asia
Primates
natural selection
Proteins
genes
proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Vasilakis, N., Holmes, E. C., Fokam, E. B., Faye, O., Diallo, M., Sall, A. A., & Weaver, S. (2007). Evolutionary processes among sylvatic dengue type 2 viruses. Journal of Virology, 81(17), 9591-9595. https://doi.org/10.1128/JVI.02776-06

Evolutionary processes among sylvatic dengue type 2 viruses. / Vasilakis, Nikos; Holmes, Edward C.; Fokam, Eric B.; Faye, Ousmane; Diallo, Mawlouth; Sall, Amadou A.; Weaver, Scott.

In: Journal of Virology, Vol. 81, No. 17, 09.2007, p. 9591-9595.

Research output: Contribution to journalArticle

Vasilakis, N, Holmes, EC, Fokam, EB, Faye, O, Diallo, M, Sall, AA & Weaver, S 2007, 'Evolutionary processes among sylvatic dengue type 2 viruses', Journal of Virology, vol. 81, no. 17, pp. 9591-9595. https://doi.org/10.1128/JVI.02776-06
Vasilakis N, Holmes EC, Fokam EB, Faye O, Diallo M, Sall AA et al. Evolutionary processes among sylvatic dengue type 2 viruses. Journal of Virology. 2007 Sep;81(17):9591-9595. https://doi.org/10.1128/JVI.02776-06
Vasilakis, Nikos ; Holmes, Edward C. ; Fokam, Eric B. ; Faye, Ousmane ; Diallo, Mawlouth ; Sall, Amadou A. ; Weaver, Scott. / Evolutionary processes among sylvatic dengue type 2 viruses. In: Journal of Virology. 2007 ; Vol. 81, No. 17. pp. 9591-9595.
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