Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses

Eryu Wang, Haolin Ni, Renling Xu, Alan Barrett, Stanley Watowich, Duane J. Gubler, Scott Weaver

Research output: Contribution to journalArticle

244 Citations (Scopus)

Abstract

Endemic/epidemic dengue viruses (DEN) that are transmitted among humans by the mosquito vectors Aedes aegypti and Aedes albopictus are hypothesized to have evolved from sylvatic DEN strains that are transmitted among nonhuman primates in West Africa and Malaysia by other Aedes mosquitoes. We tested this hypothesis with phylogenetic studies using envelope protein gene sequences of both endemic/epidemic and sylvatic strains. The basal position of sylvatic lineages of DEN-1, -2, and -4 suggested that the endemic/epidemic lineages of these three DEN serotypes evolved independently from sylvatic progenitors. Time estimates for evolution of the endemic/epidemic forms ranged from 100 to 1,500 years ago, and the evolution of endemic/epidemic forms represents relatively recent events in the history of DEN evolution. Analysis of envelope protein amino acid changes predicted to have accompanied endemic/epidemic emergence suggested a role for domain HI in adaptation to new mosquito and/or human hosts.

Original languageEnglish (US)
Pages (from-to)3227-3234
Number of pages8
JournalJournal of Virology
Volume74
Issue number7
DOIs
StatePublished - 2000

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Dengue virus
Dengue Virus
Aedes
Culicidae
Western Africa
Aedes albopictus
Malaysia
Aedes aegypti
Primates
eclosion
serotypes
Proteins
proteins
History
nucleotide sequences
Amino Acids
history
amino acids
phylogeny

ASJC Scopus subject areas

  • Immunology

Cite this

Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses. / Wang, Eryu; Ni, Haolin; Xu, Renling; Barrett, Alan; Watowich, Stanley; Gubler, Duane J.; Weaver, Scott.

In: Journal of Virology, Vol. 74, No. 7, 2000, p. 3227-3234.

Research output: Contribution to journalArticle

Wang, Eryu ; Ni, Haolin ; Xu, Renling ; Barrett, Alan ; Watowich, Stanley ; Gubler, Duane J. ; Weaver, Scott. / Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses. In: Journal of Virology. 2000 ; Vol. 74, No. 7. pp. 3227-3234.
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