TY - GEN
T1 - Exact mass measurement
T2 - 238th National Meeting and Exposition of the American Chemical Society, ACS 2009
AU - Marshall, Alan G.
AU - Blakney, Greg T.
AU - Emmett, Mark R.
AU - Hendrickson, Christopher L.
AU - Rodgers, Ryan P.
PY - 2009
Y1 - 2009
N2 - Petroleum crude oil is nature's most complex organic mixture, exhibiting >10,000 different elemental compositions (not counting isomers) within a dynamic range of 10,000:1 in a single mass spectrum. Petroleum provides an excellent template for improving mass resolution and mass accuracy for other applications. For example, the same mass isobars (i.e., two compounds of different chemical formula but the same nominal (nearest integer) mass appear in both petroleum and proteins (e.g., SH4 vs. C3, differing by 0.036 Da). Recently, we have achieved broadband "phasing" of Fourier transform ion cyclotron resonance mass spectra, based on resolution of multiple isobars at each nominal mass in a petroleum spectrum. Moreover, small systematic mass measurement errors with periodicity less than 1 Da become observable in petroleum FT-ICR mass spectra, for potential five-fold reduction in baseline noise. Several biological applications will be described. Supported by NSF DMR-0654118, NIH R01 GM78359 and the State of Florida.
AB - Petroleum crude oil is nature's most complex organic mixture, exhibiting >10,000 different elemental compositions (not counting isomers) within a dynamic range of 10,000:1 in a single mass spectrum. Petroleum provides an excellent template for improving mass resolution and mass accuracy for other applications. For example, the same mass isobars (i.e., two compounds of different chemical formula but the same nominal (nearest integer) mass appear in both petroleum and proteins (e.g., SH4 vs. C3, differing by 0.036 Da). Recently, we have achieved broadband "phasing" of Fourier transform ion cyclotron resonance mass spectra, based on resolution of multiple isobars at each nominal mass in a petroleum spectrum. Moreover, small systematic mass measurement errors with periodicity less than 1 Da become observable in petroleum FT-ICR mass spectra, for potential five-fold reduction in baseline noise. Several biological applications will be described. Supported by NSF DMR-0654118, NIH R01 GM78359 and the State of Florida.
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M3 - Conference contribution
AN - SCOPUS:78649789161
SN - 9780841200050
T3 - ACS National Meeting Book of Abstracts
BT - American Chemical Society - 238th National Meeting and Exposition, ACS 2009, Abstracts of Scientific Papers
Y2 - 16 August 2009 through 20 August 2009
ER -