Examining the Potential Effect of a Salt Sensitivity Biomarker in Korean American Immigrants: A Pilot Study

Jisook Ko; Moonju Lee; Darpan I. Patel; Vivian Nguyen; Jing Wang

doi:10.1007/s10903-021-01253-0

Examining the Potential Effect of a Salt Sensitivity Biomarker in Korean American Immigrants: A Pilot Study

Jisook Ko, Moonju Lee, Darpan I. Patel, Vivian Nguyen, Jing Wang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The genetic factors involved with salt sensitivity (SS) have been studied using a genetic approach to identify individuals at high risk for developing hypertension and could benefit from a low sodium diet intervention, but this has not been well-studied in Korean American immigrants (KAIs). The purpose of this pilot study was to investigate the influence of SS that moderates blood pressure (BP) in KAIs (n = 34). KAIs were recruited from local communities and completed a blood draw, a 8-day food log, and BP testing. The dietary sodium intake was measured using the Fitbit mobile app, and an SS biomarker was assessed using targeted genotyping. out of five GNAI2 single nucleotide polymorphisms (SNPs) tested, rs4547694 significantly moderated the relationship of dietary sodium intake on BP in KAIs. Conclusions: Further studies are warranted to test the effect of a reduced sodium diet on BP while accounting for the moderating influence of an SS genotype.

Original language	English (US)
Pages (from-to)	1161-1166
Number of pages	6
Journal	Journal of Immigrant and Minority Health
Volume	24
Issue number	5
DOIs	https://doi.org/10.1007/s10903-021-01253-0
State	Published - Oct 2022
Externally published	Yes

Keywords

Biomarker
Dietary sodium intake
Korean Americans
Salt sensitivity

ASJC Scopus subject areas

Epidemiology
Public Health, Environmental and Occupational Health

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10.1007/s10903-021-01253-0

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title = "Examining the Potential Effect of a Salt Sensitivity Biomarker in Korean American Immigrants: A Pilot Study",

abstract = "The genetic factors involved with salt sensitivity (SS) have been studied using a genetic approach to identify individuals at high risk for developing hypertension and could benefit from a low sodium diet intervention, but this has not been well-studied in Korean American immigrants (KAIs). The purpose of this pilot study was to investigate the influence of SS that moderates blood pressure (BP) in KAIs (n = 34). KAIs were recruited from local communities and completed a blood draw, a 8-day food log, and BP testing. The dietary sodium intake was measured using the Fitbit mobile app, and an SS biomarker was assessed using targeted genotyping. out of five GNAI2 single nucleotide polymorphisms (SNPs) tested, rs4547694 significantly moderated the relationship of dietary sodium intake on BP in KAIs. Conclusions: Further studies are warranted to test the effect of a reduced sodium diet on BP while accounting for the moderating influence of an SS genotype.",

keywords = "Biomarker, Dietary sodium intake, Korean Americans, Salt sensitivity",

author = "Jisook Ko and Moonju Lee and Patel, {Darpan I.} and Vivian Nguyen and Jing Wang",

note = "Publisher Copyright: {\textcopyright} 2021, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",

year = "2022",

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doi = "10.1007/s10903-021-01253-0",

language = "English (US)",

volume = "24",

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T2 - A Pilot Study

AU - Ko, Jisook

AU - Lee, Moonju

AU - Patel, Darpan I.

AU - Nguyen, Vivian

AU - Wang, Jing

PY - 2022/10

Y1 - 2022/10

N2 - The genetic factors involved with salt sensitivity (SS) have been studied using a genetic approach to identify individuals at high risk for developing hypertension and could benefit from a low sodium diet intervention, but this has not been well-studied in Korean American immigrants (KAIs). The purpose of this pilot study was to investigate the influence of SS that moderates blood pressure (BP) in KAIs (n = 34). KAIs were recruited from local communities and completed a blood draw, a 8-day food log, and BP testing. The dietary sodium intake was measured using the Fitbit mobile app, and an SS biomarker was assessed using targeted genotyping. out of five GNAI2 single nucleotide polymorphisms (SNPs) tested, rs4547694 significantly moderated the relationship of dietary sodium intake on BP in KAIs. Conclusions: Further studies are warranted to test the effect of a reduced sodium diet on BP while accounting for the moderating influence of an SS genotype.

AB - The genetic factors involved with salt sensitivity (SS) have been studied using a genetic approach to identify individuals at high risk for developing hypertension and could benefit from a low sodium diet intervention, but this has not been well-studied in Korean American immigrants (KAIs). The purpose of this pilot study was to investigate the influence of SS that moderates blood pressure (BP) in KAIs (n = 34). KAIs were recruited from local communities and completed a blood draw, a 8-day food log, and BP testing. The dietary sodium intake was measured using the Fitbit mobile app, and an SS biomarker was assessed using targeted genotyping. out of five GNAI2 single nucleotide polymorphisms (SNPs) tested, rs4547694 significantly moderated the relationship of dietary sodium intake on BP in KAIs. Conclusions: Further studies are warranted to test the effect of a reduced sodium diet on BP while accounting for the moderating influence of an SS genotype.

KW - Biomarker

KW - Dietary sodium intake

KW - Korean Americans

KW - Salt sensitivity

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ER -

Examining the Potential Effect of a Salt Sensitivity Biomarker in Korean American Immigrants: A Pilot Study

Abstract

Keywords

ASJC Scopus subject areas

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