Excess sucrose and glucose ingestion acutely elevate blood pressure in spontaneously hypertensive rats

Mohmed el Zein, Jorge L. Areas, Joseph Knapka, Philip MacCarthy, Ayub K. Yousufi, Donald DiPette, Bryan Holland, Ranjana Goel, Harry G. Preuss

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Spontaneously hypertensive rats (SHR) were fed 6 different diets. The baseline diet (I) derived equal calories from sucrose, proteins, and fats. Three other diets (II, III, VI) derived the majority of calories from refined CHO, sucrose or glucose, with decreases in calories from proteins or fats. The last two diets (IV, V) were relatively low in sucrose with a higher percentage of the total calories from proteins and fats, respectively. From 3 to 15 weeks on the diets, the highest average BP was in rats consuming high concentrations of sucrose or glucose (II, III, VI). Urinary excretory rates of nor-epinephrine (NE) at 5, 10 and 15 weeks and epinephrine at 5 and 10 weeks were significantly elevated in rats ingesting diets high in refined CHO, and NE positively correlated with blood pressure (BP) at 5 and 10 weeks of the study. At the end of the study, serum insulin levels were not different, but plasma renin and serum glucagon levels were lower in SHR consuming the diets with high CHO concentrations. We conclude that equally elevated BP are seen with relatively high intakes of either sucrose or glucose, whether the balance of calories is derived from lessening fat or protein. This is secondary, at least in part, to alterations in NE metabolism.

Original languageEnglish (US)
Pages (from-to)380-386
Number of pages7
JournalAmerican journal of hypertension
Issue number5
StatePublished - May 1990
Externally publishedYes


  • Blood pressure
  • CHO-Induced hypertension
  • Effects of refined CHO

ASJC Scopus subject areas

  • Internal Medicine


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