@inbook{5072c45df63040eabe91b27b602428a8,
title = "Excitable domains of myelinated nerves: Axon initial segments and nodes of ranvier",
abstract = "Neurons are highly polarized cells. They can be subdivided into at least two structurally and functionally distinct domains: somatodendritic and axonal domains. The somatodendritic domain receives and integrates upstream input signals, and the axonal domain generates and relays outputs in the form of action potentials to the downstream target. Demand for quick response to the harsh surroundings prompted evolution to equip vertebrates' neurons with a remarkable glia-derived structure called myelin. Not only Insulating the axon, myelinating glia also rearrange the axonal components and elaborate functional subdomains along the axon. Proper functioning of all theses domains and subdomains is vital for a normal, efficient nervous system.",
keywords = "Axon, Cell adhesion molecule, Cytoskeleton, Extracellular matrix, Ion channel, Myelin, Polarity",
author = "Chang, {Kae Jiun} and Rasband, {Matthew N.}",
note = "Funding Information: We wish to thank Pei-Jung Lee for the graphic design of the figures. This work was supported by NIH grant R01 NS063688. We respectfully acknowledge and apologize to our colleagues whose work we have not discussed due to space limitations. ",
year = "2013",
doi = "10.1016/B978-0-12-417027-8.00005-2",
language = "English (US)",
series = "Current Topics in Membranes",
publisher = "Academic Press Inc.",
pages = "159--192",
booktitle = "Current Topics in Membranes",
}