Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle

Jared M. Dickinson, Elena Volpi, Blake Rasmussen

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The loss of skeletal muscle size and function with aging and sarcopenia may be related, in part, to an age-related muscle protein synthesis impairment. In this review, we discuss to what extent aging affects skeletal muscle protein synthesis and how nutrition and exercise can be used strategically to overcome age-related protein synthesis impairments and slow the progression of sarcopenia.

Original languageEnglish (US)
Pages (from-to)216-223
Number of pages8
JournalExercise and Sport Sciences Reviews
Volume41
Issue number4
DOIs
StatePublished - Oct 2013

Fingerprint

Sarcopenia
Muscle Proteins
Skeletal Muscle
Proteins

Keywords

  • aging
  • exercise
  • insulin
  • mTORC1
  • muscle protein synthesis
  • protein
  • sarcopenia

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle. / Dickinson, Jared M.; Volpi, Elena; Rasmussen, Blake.

In: Exercise and Sport Sciences Reviews, Vol. 41, No. 4, 10.2013, p. 216-223.

Research output: Contribution to journalArticle

@article{c2ba0f11442044aeac4194e8b1dc11f7,
title = "Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle",
abstract = "The loss of skeletal muscle size and function with aging and sarcopenia may be related, in part, to an age-related muscle protein synthesis impairment. In this review, we discuss to what extent aging affects skeletal muscle protein synthesis and how nutrition and exercise can be used strategically to overcome age-related protein synthesis impairments and slow the progression of sarcopenia.",
keywords = "aging, exercise, insulin, mTORC1, muscle protein synthesis, protein, sarcopenia",
author = "Dickinson, {Jared M.} and Elena Volpi and Blake Rasmussen",
year = "2013",
month = "10",
doi = "10.1097/JES.0b013e3182a4e699",
language = "English (US)",
volume = "41",
pages = "216--223",
journal = "Exercise and Sport Sciences Reviews",
issn = "0091-6331",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle

AU - Dickinson, Jared M.

AU - Volpi, Elena

AU - Rasmussen, Blake

PY - 2013/10

Y1 - 2013/10

N2 - The loss of skeletal muscle size and function with aging and sarcopenia may be related, in part, to an age-related muscle protein synthesis impairment. In this review, we discuss to what extent aging affects skeletal muscle protein synthesis and how nutrition and exercise can be used strategically to overcome age-related protein synthesis impairments and slow the progression of sarcopenia.

AB - The loss of skeletal muscle size and function with aging and sarcopenia may be related, in part, to an age-related muscle protein synthesis impairment. In this review, we discuss to what extent aging affects skeletal muscle protein synthesis and how nutrition and exercise can be used strategically to overcome age-related protein synthesis impairments and slow the progression of sarcopenia.

KW - aging

KW - exercise

KW - insulin

KW - mTORC1

KW - muscle protein synthesis

KW - protein

KW - sarcopenia

UR - http://www.scopus.com/inward/record.url?scp=84885173182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885173182&partnerID=8YFLogxK

U2 - 10.1097/JES.0b013e3182a4e699

DO - 10.1097/JES.0b013e3182a4e699

M3 - Article

VL - 41

SP - 216

EP - 223

JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

SN - 0091-6331

IS - 4

ER -