Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Dora Abraham; Janos Feher; Gian Luca Scuderi; Dora Szabo; Arpad Dobolyi; Melinda Cservenak; Janos Juhasz; Balazs Ligeti; Sandor Pongor; Mari Carmen Gomez-Cabrera; Jose Vina; Mitsuru Higuchi; Katsuhiro Suzuki; Istvan Boldogh; Zsolt Radak

doi:10.1016/j.exger.2018.12.005

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Dora Abraham, Janos Feher, Gian Luca Scuderi, Dora Szabo, Arpad Dobolyi, Melinda Cservenak, Janos Juhasz, Balazs Ligeti, Sandor Pongor, Mari Carmen Gomez-Cabrera, Jose Vina, Mitsuru Higuchi, Katsuhiro Suzuki, Istvan Boldogh, Zsolt Radak

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1^TG). APP/PS1^TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1^TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.

Original language	English (US)
Pages (from-to)	122-131
Number of pages	10
Journal	Experimental Gerontology
Volume	115
DOIs	https://doi.org/10.1016/j.exger.2018.12.005
State	Published - Jan 2019

Keywords

Alzheimer
Exercise
Microbiome
Probiotics

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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10.1016/j.exger.2018.12.005

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Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., Vina, J., Higuchi, M., Suzuki, K., Boldogh, I., & Radak, Z. (2019). Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome. Experimental Gerontology, 115, 122-131. https://doi.org/10.1016/j.exger.2018.12.005

Abraham, D, Feher, J, Scuderi, GL, Szabo, D, Dobolyi, A, Cservenak, M, Juhasz, J, Ligeti, B, Pongor, S, Gomez-Cabrera, MC, Vina, J, Higuchi, M, Suzuki, K, Boldogh, I & Radak, Z 2019, 'Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome', Experimental Gerontology, vol. 115, pp. 122-131. https://doi.org/10.1016/j.exger.2018.12.005

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title = "Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome",

abstract = "It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.",

keywords = "Alzheimer, Exercise, Microbiome, Probiotics",

author = "Dora Abraham and Janos Feher and Scuderi, {Gian Luca} and Dora Szabo and Arpad Dobolyi and Melinda Cservenak and Janos Juhasz and Balazs Ligeti and Sandor Pongor and Gomez-Cabrera, {Mari Carmen} and Jose Vina and Mitsuru Higuchi and Katsuhiro Suzuki and Istvan Boldogh and Zsolt Radak",

note = "Funding Information: This study was supported by OTKA ( 112810 ) and National Excellence Program ( 126823 ) grants awarded to Z.R. Authors acknowledge the assistance of Professor A.W. Taylor in the preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018",

year = "2019",

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doi = "10.1016/j.exger.2018.12.005",

language = "English (US)",

volume = "115",

pages = "122--131",

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AU - Abraham, Dora

AU - Feher, Janos

AU - Scuderi, Gian Luca

AU - Szabo, Dora

AU - Dobolyi, Arpad

AU - Cservenak, Melinda

AU - Juhasz, Janos

AU - Ligeti, Balazs

AU - Pongor, Sandor

AU - Gomez-Cabrera, Mari Carmen

AU - Vina, Jose

AU - Higuchi, Mitsuru

AU - Suzuki, Katsuhiro

AU - Boldogh, Istvan

AU - Radak, Zsolt

N1 - Funding Information: This study was supported by OTKA ( 112810 ) and National Excellence Program ( 126823 ) grants awarded to Z.R. Authors acknowledge the assistance of Professor A.W. Taylor in the preparation of the manuscript. Publisher Copyright: © 2018

PY - 2019/1

Y1 - 2019/1

N2 - It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.

AB - It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1TG). APP/PS1TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.

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Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Abstract

Keywords

ASJC Scopus subject areas

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